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Literature summary extracted from

  • Kusudo, T.; Sakaki, T.; Abe, D.; Fujishima, T.; Kittaka, A.; Takayama, H.; Hatakeyama, S.; Ohta, M.; Inouye, K.
    Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1 (2004), Biochem. Biophys. Res. Commun., 321, 774-782.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.16 expressed in Escherichia coli JM109 cells Homo sapiens
1.14.15.16 expressed in Escherichia coli JM109 cells Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.15.16 0.00006
-
 1alpha,25-dihydroxyvitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens
1.14.15.16 0.00006
-
 1beta,25-dihydroxyvitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens
1.14.15.16 0.00015
-
 1alpha,25-dihydroxy-3-epi-vitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens
1.14.15.16 0.00018
-
 25-hydroxyvitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens
1.14.15.16 0.0012
-
 1beta,25-dihydroxy-3-epi-vitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.16 Homo sapiens
-
-
-
1.14.15.16 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.16 1alpha,25-dihydroxy-3-epi-vitamin D3 + NADPH + H+ + O2
-
 Homo sapiens ?
-
 ?
1.14.15.16 1alpha,25-dihydroxy-3-epivitamin-D3 + NADPH + H+ + O2
-
 Rattus norvegicus ?
-
 ?
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Rattus norvegicus 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 1beta,25-dihydroxy-3-epi-vitamin D3 + NADPH + H+ + O2
-
 Homo sapiens ?
-
 ?
1.14.15.16 1beta,25-dihydroxy-3-epivitamin-D3 + NADPH + H+ + O2
-
 Rattus norvegicus ?
-
 ?
1.14.15.16 1beta,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens ? + NADP+ + H2O
-
 ?
1.14.15.16 1beta,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Rattus norvegicus ? + NADP+ + H2O
-
 ?
1.14.15.16 25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Rattus norvegicus 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.16 CYP24A1
-
 Homo sapiens
1.14.15.16 CYP24A1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.16 NADPH
-
 Homo sapiens
1.14.15.16 NADPH
-
 Rattus norvegicus