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Literature summary extracted from

  • Shiemke, A.K.; Cook, S.A.; Miley, T.; Singleton, P.
    Detergent solubilization of membrane-bound methane monooxygenase requires plastoquinol analogs as electron donors (1995), Arch. Biochem. Biophys., 321, 421-428.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.18.3 lauryl maltoside the stimulatory effect of lauryl maltoside is responsible for the initial increase in duroquinol-dependent activity of the pellet, but no activity with NADH is observed after this solubilization Methylococcus capsulatus
1.14.18.3 additional information no pMMO acivity is observed in the detergent-solubilized fraction in the presence of dithionite, ascorbate, or methyl viologen. No pMMO activity with duroquinol or NADH is observed after solubilization with Triton X-100, Tween 20, zwittergent 3-12, Nonidet-P40, or synperonic Methylococcus capsulatus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.3 Acetylene 4.3% residual activity at 10% (v/v) Methylococcus capsulatus
1.14.18.3 cyanide less than 2% residual activity at 2 mM Methylococcus capsulatus
1.14.18.3 EDTA 18.1% residual activity at 1.5 mM Methylococcus capsulatus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.18.3 membrane
-
 Methylococcus capsulatus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.3 Cu2+ the enzyme is stimulated by exogenous copper (348% activity at 0.4 mM) Methylococcus capsulatus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.3 Methylococcus capsulatus
-
-
-
1.14.18.3 Methylococcus capsulatus Bath
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.3 Mn2+ + H2O2
-
 Methylococcus capsulatus ?
-
 ?
1.14.18.3 Mn2+ + H2O2
-
 Methylococcus capsulatus Bath ?
-
 ?
1.14.18.3 additional information quinols are effective reductants for the detergent-solubilized enzyme, whereas NADH is ineffective Methylococcus capsulatus ?
-
 ?
1.14.18.3 additional information quinols are effective reductants for the detergent-solubilized enzyme, whereas NADH is ineffective Methylococcus capsulatus Bath ?
-
 ?
1.14.18.3 propylene + 2,3-dimethylquinol + O2
-
 Methylococcus capsulatus propylene oxide + 2,3-dimethylquinone + H2O
-
 ?
1.14.18.3 propylene + 2,3-dimethylquinol + O2
-
 Methylococcus capsulatus Bath propylene oxide + 2,3-dimethylquinone + H2O
-
 ?
1.14.18.3 propylene + coenzyme Q0 + O2
-
 Methylococcus capsulatus propylene oxide + reduced coenzyme Q0 + H2O
-
 ?
1.14.18.3 propylene + coenzyme Q0 + O2
-
 Methylococcus capsulatus Bath propylene oxide + reduced coenzyme Q0 + H2O
-
 ?
1.14.18.3 propylene + decyl-plastoquinol + O2 higher activity compared to duroquinol Methylococcus capsulatus propylene oxide + decyl-plastoquinone + H2O
-
 ?
1.14.18.3 propylene + decyl-plastoquinol + O2 higher activity compared to duroquinol Methylococcus capsulatus Bath propylene oxide + decyl-plastoquinone + H2O
-
 ?
1.14.18.3 propylene + decylubiquinol + O2
-
 Methylococcus capsulatus propylene oxide + decylubiquinone + H2O
-
 ?
1.14.18.3 propylene + duroquinol + O2
-
 Methylococcus capsulatus propylene oxide + duroquinone + H2O
-
 ?
1.14.18.3 propylene + menaquinol + O2
-
 Methylococcus capsulatus propylene oxide + menaquinone + H2O
-
 ?
1.14.18.3 propylene + trimethylquinol + O2
-
 Methylococcus capsulatus propylene oxide + trimethylquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.3 pMMO
-
 Methylococcus capsulatus