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Literature summary extracted from

  • Arakawa, C.; Kuratsu, M.; Furihata, K.; Hiratsuka, T.; Itoh, N.; Seto, H.; Dairi, T.
    Diversity of the early step of the futalosine pathway (2011), Antimicrob. Agents Chemother., 55, 913-916.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.2.2.26 medicine MqnB in Helicobacter pylori is an attractive target for the development of specific anti-Helicobacter pylori drugs Helicobacter pylori

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.40
-
 Acidothermus cellulolyticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.30 6-amino-6-deoxyfutalosine + H2O Helicobacter pylori
-
 dehypoxanthine futalosine + adenine
-
 ?
3.5.4.40 6-amino-6-deoxyfutalosine + H2O Acidothermus cellulolyticus the enzyme is part of the futalosine pathway for menaquinone biosynthesis futalosine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.26 Acidothermus cellulolyticus
-
-
-
3.2.2.26 Helicobacter pylori
-
-
-
3.2.2.26 Streptomyces coelicolor
-
-
-
3.2.2.30 Helicobacter pylori
-
-
-
3.5.4.40 Acidothermus cellulolyticus A0LRH8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.26 aminodeoxyfutalosine + H2O
-
 Helicobacter pylori dehypoxanthine futalosine + adenine
-
 ?
3.2.2.26 futalosine + H2O
-
 Streptomyces coelicolor dehypoxanthine futalosine + hypoxanthine
-
 ?
3.2.2.26 futalosine + H2O
-
 Acidothermus cellulolyticus dehypoxanthine futalosine + hypoxanthine
-
 ?
3.2.2.26 additional information no activity with aminodeoxyfutalosine Streptomyces coelicolor ?
-
 ?
3.2.2.30 6-amino-6-deoxyfutalosine + H2O
-
 Helicobacter pylori dehypoxanthine futalosine + adenine
-
 ?
3.5.4.40 6-amino-6-deoxyfutalosine + H2O the enzyme is part of the futalosine pathway for menaquinone biosynthesis Acidothermus cellulolyticus futalosine + NH3
-
 ?
3.5.4.40 6-amino-6-deoxyfutalosine + H2O 6-amino-6-deoxyfutalosine i.e. 3-[3-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]propanoyl]benzoate Acidothermus cellulolyticus futalosine + NH3 futalosine i.e. 3-[3-[(3S,4R)-3,4-dihydroxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl]propanoyl]benzoate ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.26 MqnB
-
 Streptomyces coelicolor
3.2.2.26 MqnB
-
 Helicobacter pylori
3.2.2.26 MqnB
-
 Acidothermus cellulolyticus
3.2.2.30 futalosine hydrolase
-
 Helicobacter pylori
3.2.2.30 MqnB
-
 Helicobacter pylori
3.5.4.40 Acel_0264
-
 Acidothermus cellulolyticus
3.5.4.40 AFL deaminase
-
 Acidothermus cellulolyticus
3.5.4.40 aminofutalosine deaminase
-
 Acidothermus cellulolyticus
3.5.4.40 mqnX
-
 Acidothermus cellulolyticus

General Information

EC Number General Information Comment Organism
3.5.4.40 physiological function the enzyme is part of the futalosine pathway for menaquinone biosynthesis Acidothermus cellulolyticus