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Literature summary extracted from

  • Goto, K.; Sonoda, D.; Shimada, K.; Sase, S.; Kawashima, T.
    Modeling of the 5'-deiodination of thyroxine by iodothyronine deiodinase: Chemical corroboration of a selenenyl iodide intermediate (2010), Angew. Chem., 49, 545-547.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Homo sapiens
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 L-thyroxine + AH2
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 Homo sapiens 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.4 additional information the catalytic cycle of ID-1 involves a ping-pong bisubstrate reaction in which the selenol form of the enzyme (ESeH) reacts with L-thyroxine to form a selenenyl iodide intermediate (ESeI) with release of the deiodinated compound 3,5,3'-triiodo-L-thyronine, and a subsequent reaction between the selenenyl iodide intermediate and possibly a thiol cofactor regenerates the selenol form Homo sapiens ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 ID-1
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 Homo sapiens
1.21.99.4 type I iodothyronine deiodinase
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 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.21.99.4 dithioerythritol
-
 Homo sapiens