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Literature summary extracted from

  • Cole, T.B.; Jansen, K.; Park, S.; Li, W.F.; Furlong, C.E.; Costa, L.G.
    The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status (2010), Adv. Exp. Med. Biol., 660, 47-60.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.8.1 PON1 the mutant is less able to detoxify diazoxon Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.8.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.8.1 serum
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.8.1 chlorpyrifos oxon + H2O
-
 Mus musculus 3,5,6-trichloro-pyridin-2-ol + diethyl phosphate
-
 ?
3.1.8.1 diazoxon + H2O
-
 Mus musculus 2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate
-
 ?
3.1.8.1 paraoxon + H2O
-
 Mus musculus 4-nitrophenol + diethyl phosphate
-
 ?

General Information

EC Number General Information Comment Organism
3.1.8.1 malfunction paraoxonase 1 knockout mice are dramatically more sensitive than wild type mice to the toxicity of chlorpyrifos oxon and diazoxon and to a lesser extent the parent phosphorothioates, chlorpyrifos and diazinon Mus musculus
3.1.8.1 physiological function paraoxonase 1 modulates the toxicity of organophosphorous mixtures (paraoxon, chlorpytifoy oxon, diazoxon) by altering the activity of another detoxication enzyme, carboxylesterase Mus musculus