EC Number | Cloned (Comment) | Organism |
---|---|---|
5.3.99.2 | expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
5.3.99.2 | H-PGDS is crystallized in a microgravity environment at 20°C, using 30% (w/v) PEG 6000, 10 mM dithiothreitol, 10 mM glutathione, 1% (v/v) dioxane and 1 mM magnesium chloride in 50 mM Tris-HCl pH 8.4 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.3.99.2 | HQL-79 | i.e. 4-benzhydryloxy-1-[3-(1H-tetrazol-5-yl)-propyl]-piperidine, H-PGDS-specific inhibitor | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.2 | Prostaglandin H2 | Homo sapiens | - |
Prostaglandin D2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.99.2 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
5.3.99.2 | glutathione-Sepharose column chromatography and Mono-Q column chromatography | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.3.99.2 | mast cell | - |
Homo sapiens | - |
5.3.99.2 | Th2-cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.2 | Prostaglandin H2 | - |
Homo sapiens | Prostaglandin D2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.99.2 | H-PGDS | - |
Homo sapiens |
5.3.99.2 | haematopoietic PGD synthase | - |
Homo sapiens |
5.3.99.2 | haematopoietic prostaglandin D synthase | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
5.3.99.2 | 0.0059 | - |
pH and temperature not specified in the publication | Homo sapiens | HQL-79 |