BRENDA - Enzyme Database

Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein

Tachibana, T.; Kato, M.; Watanabe, T.; Mitsui, T.; Sugiyama, Y.; Xenobiotica 39, 430-443 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
7.6.2.2
medicine
development of a method for predicting the risk of drug-drug interactions involving inhibition of P-glycoprotein
Homo sapiens
Organism
EC Number
Organism
UniProt
Commentary
Textmining
7.6.2.2
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
7.6.2.2
ATP + H2O + digoxin/in
-
713592
Homo sapiens
ADP + phosphate + digoxin/out
-
-
-
?
7.6.2.2
ATP + H2O + fexofenadine/in
-
713592
Homo sapiens
ADP + phosphate + fexofenadine/out
-
-
-
?
7.6.2.2
ATP + H2O + talinolol/in
-
713592
Homo sapiens
ADP + phosphate + talinolol/out
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
7.6.2.2
P-glycoprotein
-
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
7.6.2.2
medicine
development of a method for predicting the risk of drug-drug interactions involving inhibition of P-glycoprotein
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
7.6.2.2
ATP + H2O + digoxin/in
-
713592
Homo sapiens
ADP + phosphate + digoxin/out
-
-
-
?
7.6.2.2
ATP + H2O + fexofenadine/in
-
713592
Homo sapiens
ADP + phosphate + fexofenadine/out
-
-
-
?
7.6.2.2
ATP + H2O + talinolol/in
-
713592
Homo sapiens
ADP + phosphate + talinolol/out
-
-
-
?