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Literature summary extracted from

  • Niwa, K.; Yoneyama, T.; Ito, H.; Taira, M.; Chikai, T.; Kouguchi, H.; Suzuki, T.; Hasegawa, K.; Miyata, K.; Inui, K.; Ikeda, T.; Watanabe, T.; Ohyama, T.
    Sialic acid-dependent binding and transcytosis of serotype D botulinum neurotoxin and toxin complex in rat intestinal epithelial cells (2010), Vet. Microbiol., 141, 312-320.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.69 N-acetyl neuraminic acid both binding and permeation of toxins are potently inhibited by N-acetyl neuraminic acid in the cell culture mediumor by treatment of the cells with neuraminidase, but neither galactose, lactose nor N-acetyl galactosamine inhibit binding or permeation of toxins Clostridium botulinum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.69 additional information Clostridium botulinum sialic acid-dependent binding is required for the transcytosis of serotype D botulinum neurotoxin and toxin complex L-TC in rat intestinal epithelial cell line IEC-6, mechanism, overview. HA-33 molecules play an important role in the effective binding of D-4947 L-TC to Caco-2 cells ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.69 Clostridium botulinum
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 strain 4947, BoNT/D
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Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.69 BoNT serotype D and enzyme large toxin complex, L-TC, from strain 4947, by ammonium sulfate fractionation, cation exchange chromatography, another step of ammonium sulfate fractionation, and gel filtration Clostridium botulinum

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.69 additional information sialic acid-dependent binding is required for the transcytosis of serotype D botulinum neurotoxin and toxin complex L-TC in rat intestinal epithelial cell line IEC-6, mechanism, overview. HA-33 molecules play an important role in the effective binding of D-4947 L-TC to Caco-2 cells Clostridium botulinum ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.69 BoNT
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 Clostridium botulinum
3.4.24.69 D-4947 L-TC
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 Clostridium botulinum
3.4.24.69 serotype D botulinum neurotoxin
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 Clostridium botulinum

General Information

EC Number General Information Comment Organism
3.4.24.69 additional information A large toxin complex, L-TC, produced by Clostridium botulinum is composed of neurotoxin BoNT, non-toxic non-hemagglutinin, and hemagglutinin subcomponents, HA-70, -33 and -17 Clostridium botulinum