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Literature summary extracted from

  • Kiran, M.; Chauhan, A.; Dziedzic, R.; Maloney, E.; Mukherji, S.K.; Madiraju, M.; Rajagopalan, M.
    Mycobacterium tuberculosis ftsH expression in response to stress and viability (2009), Tuberculosis, 89 Suppl 1, S70-S73.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B20 gene ftsh, expression in Escherichia coli Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B20 Mycobacterium tuberculosis
-
 gene ftsH
-
3.4.24.B20 Mycobacterium tuberculosis H37Rv
-
 gene ftsH
-

Expression

EC Number Organism Comment Expression
3.4.24.B20 Mycobacterium tuberculosis ftsH expression levels are upregulated upon exposure to agents that produce reactive oxygen and nitrogen intermediates and growth in macrophages up

General Information

EC Number General Information Comment Organism
3.4.24.B20 physiological function FtsH is an essential membrane-bound protease that degrades integral membrane proteins as well as cytoplasmic proteins. FtsH is a stress-response protein that promotes the pathogen's ability to deal with reactive oxygen intermediates stress and is possibly involved in the regulation of FtsZ levels. Optimal intracellular levels of the essential cell-division protein FtsZ are critical for cell division and viability, overview Mycobacterium tuberculosis