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Literature summary extracted from

  • Kollock, R.; Rost, K.; Batke, M.; Glatt, H.
    Effect of pentachlorophenol and 2,6-dichloro-4-nitrophenol on the activity of cDNA-expressed human alcohol and aldehyde dehydrogenases (2009), Toxicol. Lett., 191, 360-364.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.3 expressed in Salmonella typhimurium strain TA100 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 2,6-Dichloro-4-nitrophenol primarily inhibits isoform ALDH2 (non-competitive), but does not affect isoform ALDH3A1 Homo sapiens
1.2.1.3 additional information activities of isoforms ALDH2 and ALDH3A1 are unaffected by pentachlorophenol (up to a concentration of 1 mM) Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 formaldehyde + NAD+ + H2O
-
 Homo sapiens formate + NADH + H+
-
 ?
1.2.1.3 propionaldehyde + NAD+ + H2O
-
 Homo sapiens propionate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALDH2 isoform Homo sapiens
1.2.1.3 ALDH3A1 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.3 0.0074
-
 2,6-Dichloro-4-nitrophenol isoform ALDH2, in 0.1 M sodium diphosphate buffer (pH 9.5), at 21-23°C Homo sapiens