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Literature summary extracted from

  • van Boxtel, A.L.; Kamstra, J.H.; Fluitsma, D.M.; Legler, J.
    Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activity (2010), Toxicol. Appl. Pharmacol., 244, 156-161.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.13 beta-aminopropionitrile
-
 Danio rerio
1.4.3.13 Disulfiram a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview Danio rerio
1.4.3.13 thiram a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview Danio rerio

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.13 Cu2+ dependent on Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.13 Danio rerio
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.13 embryo
-
 Danio rerio
-

Synonyms

EC Number Synonyms Comment Organism
1.4.3.13 LOX
-
 Danio rerio
1.4.3.13 lysyl oxidase
-
 Danio rerio

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.13 8.2
-
 assay at Danio rerio

General Information

EC Number General Information Comment Organism
1.4.3.13 additional information partial knockdown of three LOX genes, lox,loxl1 and loxl5b, sensitizes the developing embryo to dithiocarbamate exposure Danio rerio