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Literature summary extracted from

  • Tóth, I.; Szécsi, M.; Julesz, J.; Faredin I.
    Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-isomerase in human skin (1997), Skin Pharmacol. Physiol., 10, 160-168.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.51 4-MA
-
 Homo sapiens
1.1.1.51 cyproterone acetate
-
 Homo sapiens
1.1.1.51 epostane
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.51 0.00001
-
 dehydroepiandrosterone 37°C, pH not specified in the publication Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 skin
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.51 0.00000000935
-
 female abdominal skin, mean value, n=4, 37°C, pH not specified in the publication Homo sapiens
1.1.1.51 0.0000000122
-
 male inguinal skin, mean value, n=8, 37°C, pH not specified in the publication Homo sapiens
1.1.1.51 0.0000000213
-
 female perineal skin, mean value, n=4, 37°C, pH not specified in the publication Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 dehydroepiandrosterone + NAD+
-
 Homo sapiens androstene-3,17-dione + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 3beta-hydroxysteroid dehydrogenase/DELTA5-4-isomerase
-
 Homo sapiens
1.1.1.51 DELTA5-3beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.51 0.00000145
-
 37°C, pH not specified in the publication Homo sapiens 4-MA
1.1.1.51 0.0000062
-
 37°C, pH not specified in the publication Homo sapiens epostane
1.1.1.51 0.00015
-
 37°C, pH not specified in the publication Homo sapiens cyproterone acetate