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Literature summary extracted from

  • Kim, I.A.; No, M.; Lee, J.M.; Shin, J.H.; Oh, J.S.; Choi, E.J.; Kim, I.H.; Atadja, P.; Bernhard, E.J.
    Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: potential role of histone deacetylase 6 (2009), Radiother. Oncol., 92, 125-132.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 LBH589 pan-histone deacetylase inhibitor Homo sapiens
3.5.1.98 SK7041 i.e. 4-dimethylamino-N-[4-(2-hydroxylcarbamoyl-vinyl)benzyl] benzamide Homo sapiens
3.5.1.98 trichostatin A
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.98 N-acetyl-lysine-alpha-tubulin + H2O Homo sapiens
-
 acetate + alpha-tubulin
-
 ?
3.5.1.98 N-acetyl-lysine-heat shock protein 90 + H2O Homo sapiens
-
 acetate + heat shock protein 90
-
 ?
3.5.1.98 N-acetyl-lysine-histone H3 + H2O Homo sapiens
-
 acetate + histone H3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 MCF-7 cell
-
 Homo sapiens
-
3.5.1.98 SK-BR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.98 N-acetyl-lysine-alpha-tubulin + H2O
-
 Homo sapiens acetate + alpha-tubulin
-
 ?
3.5.1.98 N-acetyl-lysine-heat shock protein 90 + H2O
-
 Homo sapiens acetate + heat shock protein 90
-
 ?
3.5.1.98 N-acetyl-lysine-histone H3 + H2O
-
 Homo sapiens acetate + histone H3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC6
-
 Homo sapiens
3.5.1.98 histone deacetylase 6
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.5.1.98 physiological function ectopic overexpression of HDAC6 isotype increases the levels of phosphorylated epidermal growth factor receptor and phosphorylated AKT expression. HDAC6 plays an important role in the modulation of radiation response of epidermal growth factor receptor and human epidermal growth factor receptor 2-activated cells Homo sapiens