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Literature summary extracted from

  • Capece, L.; Arrar, M.; Roitberg, A.E.; Yeh, S.R.; Marti, M.A.; Estrin, D.A.
    Substrate stereo-specificity in tryptophan dioxygenase and indoleamine 2,3-dioxygenase (2010), Proteins, 78, 2961-2972.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.52 0.015
-
 L-tryptophan pH and temperature not specified in the publication Homo sapiens
1.13.11.52 0.114
-
 L-tryptophan pH and temperature not specified in the publication Xanthomonas campestris
1.13.11.52 2.6
-
 D-tryptophan pH and temperature not specified in the publication Homo sapiens
1.13.11.52 16
-
 D-tryptophan pH and temperature not specified in the publication Xanthomonas campestris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 D-tryptophan + O2 Homo sapiens IDO displays a similar kcat for D- and L-tryptophan, but D-tryptophan has 173folds higher Km N-formyl-D-kynurenine
-
 ?
1.13.11.52 D-tryptophan + O2 Xanthomonas campestris while L and D-tryptophan have similar affinities (Km values), the kcat is 10times lower for D-tryptophan N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Homo sapiens IDO displays a similar kcat for D- and L-tryptophan, but D-tryptophan has 173folds higher Km N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Xanthomonas campestris while L and D-tryptophan have similar affinities (Km values), the kcat is 10times lower for D-tryptophan N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens P14902
-
-
1.13.11.52 Xanthomonas campestris Q8PDA8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 additional information IDO is found ubiquitously in all tissues Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-tryptophan + O2 IDO displays a similar kcat for D- and L-tryptophan, but D-tryptophan has 173folds higher Km Homo sapiens N-formyl-D-kynurenine
-
 ?
1.13.11.52 D-tryptophan + O2 while L and D-tryptophan have similar affinities (Km values), the kcat is 10times lower for D-tryptophan Xanthomonas campestris N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 IDO displays a similar kcat for D- and L-tryptophan, but D-tryptophan has 173folds higher Km Homo sapiens N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 while L and D-tryptophan have similar affinities (Km values), the kcat is 10times lower for D-tryptophan Xanthomonas campestris N-formyl-L-kynurenine
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.52 monomer x-ray crystallography Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 IDO
-
 Homo sapiens
1.13.11.52 TDO
-
 Xanthomonas campestris

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Homo sapiens