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Literature summary extracted from
- Anthrax toxin uptake by primary immune cells as determined with a lethal factor-beta-lactamase fusion protein (2009), PLoS ONE, 4, e7946.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.83 | medicine | anthrax toxin entry and activity differs among immune cells. Macrophages, dendritic cells, and B cells display higher activity of a of fusion protein of the anthrax toxin lethal factor N-terminal domain LFn, residues 1-254, with beta-lactamase, i.e. LFnBLA, than CD4+ and CD8+ T cells in both spleen cell suspension and the purified samples of individual cell types. Expression of anthrax toxin receptor CMG2 is higher in CD4+ and CD8+ T cells, which is not correlated to the intracellular LFnBLA activity | Bacillus anthracis |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.24.83 | additional information | construction of fusion protein of the anthrax toxin lethal factor N-terminal domain LFn, residues 1-254, with beta-lactamase | Bacillus anthracis |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.83 | Bacillus anthracis | - |
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