Literature summary extracted from

Bhandari, J.; Fitzpatrick, A.H.; Crowell, D.N.
Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis thaliana (2010), Plant Physiol., 154, 1116-1127.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.354	overexpression of recombinant Arabidopsis farnesol dehydrogenase activity in Saccharomyces cerevisiae strain SM1058 using pCL196 plasmid	Arabidopsis thaliana

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.354	Arabidopsis thaliana	Q9SZB3	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.354	(2E,6E)-farnesol + NAD+	highest affinity for the active site of the FLDH enzyme, FLDH-encoded enzyme does not exhibit appreciable farnesal reductase activity	Arabidopsis thaliana	(2E,6E)-farnesal + NADH + H+	-	ir
1.1.1.354	geraniol + NAD+	-	Arabidopsis thaliana	geranial + NADH + H+	-	?
1.1.1.354	geranylgeraniol + NAD+	-	Arabidopsis thaliana	? + NADH + H+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.354	farnesol dehydrogenase	-	Arabidopsis thaliana

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.354	NAD+	no oxidation observed in the presence of NADP+	Arabidopsis thaliana

Expression

EC Number	Organism	Comment	Expression
1.1.1.354	Arabidopsis thaliana	FLDH expression is repressed by exogenous abscisic acid and FLDH expression negatively regulates ABA signaling	down
1.1.1.354	Arabidopsis thaliana	expression is increased in mutants with T-DNA insertions in the FLDH 5' flanking region indicating that both T-DNA insertions disrupt a cis-acting negative regulatory element in the FLDH promoter	up

General Information

EC Number	General Information	Comment	Organism
1.1.1.354	physiological function	results suggest that FLDH is a negative regulator of ABA signaling	Arabidopsis thaliana

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Release 2023.1 (January 2023)