BRENDA - Enzyme Database

Cytosolic NADP-dependent isocitrate dehydrogenase contributes to redox homeostasis and the regulation of pathogen responses in Arabidopsis leaves

Mhamdi, A.; Mauve, C.; Gouia, H.; Saindrenan, P.; Hodges, M.; Noctor, G.; Plant Cell Environ. 33, 1112-1123 (2010)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
1.1.1.42
isozyme cICDH is encoded by a single gene
Arabidopsis thaliana
Engineering
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.42
additional information
introduction of an icdh mutation into the cat2 background, in which increased availability of H2O2 causes perturbed redox homeostasis and induction of stress-related genes. Accumulation of oxidized glutathione and pathogen-related responses are enhanced in double cat2 icdh mutants compared to cat2. Single icdh mutants present constitutive induction of PR genes, enhanced resistance to bacteria in icdh, cat2 and cat2 icdh is quantitatively correlated with PR gene expression. However, the effect of icdh in both Col0 and cat2 backgrounds is not associated with enhanced accumulation of salicylic acid, phenotypes, overview
Arabidopsis thaliana
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.42
cytosol
isozyme cICDH
Arabidopsis thaliana
5829
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Arabidopsis thaliana
-
2-oxoglutarate + NADPH + H+ + CO2
-
-
?
1.1.1.42
isocitrate + NADP+
Arabidopsis thaliana Columbia ecotype
-
2-oxoglutarate + NADPH + H+ + CO2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.42
Arabidopsis thaliana
-
gene icdh
-
1.1.1.42
Arabidopsis thaliana Columbia ecotype
-
gene icdh
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
leaf
-
Arabidopsis thaliana
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
713246
Arabidopsis thaliana
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
713246
Arabidopsis thaliana Columbia ecotype
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Arabidopsis thaliana
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.42
isozyme cICDH is encoded by a single gene
Arabidopsis thaliana
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Arabidopsis thaliana
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.42
additional information
introduction of an icdh mutation into the cat2 background, in which increased availability of H2O2 causes perturbed redox homeostasis and induction of stress-related genes. Accumulation of oxidized glutathione and pathogen-related responses are enhanced in double cat2 icdh mutants compared to cat2. Single icdh mutants present constitutive induction of PR genes, enhanced resistance to bacteria in icdh, cat2 and cat2 icdh is quantitatively correlated with PR gene expression. However, the effect of icdh in both Col0 and cat2 backgrounds is not associated with enhanced accumulation of salicylic acid, phenotypes, overview
Arabidopsis thaliana
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.42
cytosol
isozyme cICDH
Arabidopsis thaliana
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Arabidopsis thaliana
-
2-oxoglutarate + NADPH + H+ + CO2
-
-
?
1.1.1.42
isocitrate + NADP+
Arabidopsis thaliana Columbia ecotype
-
2-oxoglutarate + NADPH + H+ + CO2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
leaf
-
Arabidopsis thaliana
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
713246
Arabidopsis thaliana
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
713246
Arabidopsis thaliana Columbia ecotype
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
1.1.1.42
physiological function
cICDH is involved in amino acid synthesis, and plays a role in redox signalling linked to pathogen responses, but cICDH is not required for plant development and primary metabolism in optimal growth conditions
Arabidopsis thaliana
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.1.1.42
physiological function
cICDH is involved in amino acid synthesis, and plays a role in redox signalling linked to pathogen responses, but cICDH is not required for plant development and primary metabolism in optimal growth conditions
Arabidopsis thaliana