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Literature summary extracted from
- Rare merosesquiterpenoids from basidiomycete Craterellus odoratus and their inhibition of 11beta-hydroxysteroid dehydrogenases (2010), Phytochemistry, 71, 100-103.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.1.1.B40 | expressed in HEK-293 cell | Homo sapiens |
| 1.1.1.146 | expressed in HEK-293 cell | Mus musculus |
| 1.1.1.146 | expressed in HEK-293 cell | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.B40 | (1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol | - |
Homo sapiens |  |
| 1.1.1.B40 | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aR,6S,8aR)-6-hydroxy-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | - |
Homo sapiens | |
| 1.1.1.B40 | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | - |
Homo sapiens | |
| 1.1.1.B40 | (2E,4S)-4-hydroxy-5-[(1S,5S,6S)-6-(hydroxymethyl)-2-methylidenebicyclo[3.1.1]hept-6-yl]-2-methylpent-2-enoic acid | - |
Homo sapiens | |
| 1.1.1.B40 | glycyrrhizinic acid | - |
Homo sapiens | |
| 1.1.1.146 | (1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol | - |
Homo sapiens | |
| 1.1.1.146 | (1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol | - |
Mus musculus | |
| 1.1.1.146 | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aR,6S,8aR)-6-hydroxy-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | - |
Homo sapiens | |
| 1.1.1.146 | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aR,6S,8aR)-6-hydroxy-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | - |
Mus musculus | |
| 1.1.1.146 | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | - |
Homo sapiens | |
| 1.1.1.146 | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | - |
Mus musculus | |
| 1.1.1.146 | (2E,4S)-4-hydroxy-5-[(1S,5S,6S)-6-(hydroxymethyl)-2-methylidenebicyclo[3.1.1]hept-6-yl]-2-methylpent-2-enoic acid | - |
Homo sapiens | |
| 1.1.1.146 | (2E,4S)-4-hydroxy-5-[(1S,5S,6S)-6-(hydroxymethyl)-2-methylidenebicyclo[3.1.1]hept-6-yl]-2-methylpent-2-enoic acid | - |
Mus musculus | |
| 1.1.1.146 | glycyrrhizinic acid | - |
Homo sapiens | |
| 1.1.1.146 | glycyrrhizinic acid | - |
Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.B40 | microsome | - |
Homo sapiens | - |
- |
| 1.1.1.146 | microsome | - |
Mus musculus | - |
- |
| 1.1.1.146 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.B40 | Homo sapiens | - |
- |
- |
| 1.1.1.146 | Homo sapiens | - |
- |
- |
| 1.1.1.146 | Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.B40 | cortisol + NAD+ | - |
Homo sapiens | cortisone + NADH + H+ | - |
? | |
| 1.1.1.146 | cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? | |
| 1.1.1.146 | cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.B40 | NAD+ | - |
Homo sapiens | |
| 1.1.1.146 | NADP+ | - |
Mus musculus | |
| 1.1.1.146 | NADP+ | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.B40 | additional information | - |
IC50 = 0.0015 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | |
| 1.1.1.B40 | additional information | - |
IC50 = 0.0106 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (2E,4S)-4-hydroxy-5-[(1S,5S,6S)-6-(hydroxymethyl)-2-methylidenebicyclo[3.1.1]hept-6-yl]-2-methylpent-2-enoic acid | |
| 1.1.1.B40 | additional information | - |
IC50 = 0.0254 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol | |
| 1.1.1.B40 | additional information | - |
IC50 above 0.1 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aR,6S,8aR)-6-hydroxy-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | |
| 1.1.1.B40 | 0.00000071 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | glycyrrhizinic acid | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0031 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (2E,4S)-4-hydroxy-5-[(1S,5S,6S)-6-(hydroxymethyl)-2-methylidenebicyclo[3.1.1]hept-6-yl]-2-methylpent-2-enoic acid | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0035 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aR,6S,8aR)-6-hydroxy-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0091 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0148 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0197 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (2E,4S)-4-hydroxy-5-[(1S,5S,6S)-6-(hydroxymethyl)-2-methylidenebicyclo[3.1.1]hept-6-yl]-2-methylpent-2-enoic acid | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0363 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0548 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aR,6S,8aR)-6-hydroxy-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol | |
| 1.1.1.146 | additional information | - |
IC50 = 0.0933 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol | |
| 1.1.1.146 | 0.0000186 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | glycyrrhizinic acid | |
| 1.1.1.146 | 0.0000295 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | glycyrrhizinic acid | |
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