Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hudson, A.L.; Sotirchos, I.M.; Davey, M.W.
    Substrate specificity of the mitochondrial thioredoxin reductase of the parasitic nematode Haemonchus contortus (2010), Parasitol. Res., 107, 487-493.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 auranofin
-
 Haemonchus contortus
1.8.1.9 curcumin
-
 Haemonchus contortus
1.8.1.9 theaflavin
-
 Haemonchus contortus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.9 cytoplasm isoform TrxR1 Haemonchus contortus 5737
-
1.8.1.9 mitochondrion isoform TrxR2 Haemonchus contortus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.1.9 selenium TrxR1 contains a selenocysteine in the active site (Gly-Cys-SeCys-Gly) Haemonchus contortus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Haemonchus contortus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
 Haemonchus contortus 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 additional information isoform TrxR1 shows broad activity with thioredoxins from Escherichia coli, sheep, and Haemonchus contortus, while isoform TrxR2 has high activity only with the mitochondrial Haemonchus contortus thioredoxin Haemonchus contortus ?
-
 ?
1.8.1.9 selenite + NADPH + H+
-
 Haemonchus contortus ? + NADP+
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Haemonchus contortus thioredoxin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
 Haemonchus contortus
1.8.1.9 TrxR1 isoform Haemonchus contortus
1.8.1.9 TrxR2 isoform Haemonchus contortus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
 Haemonchus contortus
1.8.1.9 NADPH
-
 Haemonchus contortus