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Literature summary extracted from

  • Meng, H.; Zhang, X.; Blaivas, M.; Wang, M.M.
    Localization of blood proteins thrombospondin1 and ADAMTS13 to cerebral corpora amylacea (2009), Neuropathology, 29, 664-671.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.87 expression of FLAG-tagged ADAMTS13 in HEK-293 cells, co-expression with thrombospondin1 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 extracellular secreted enzyme Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 additional information Homo sapiens thrombospondin1 and ADAMTS13 form complexes together in cells and in direct protein binding assays ?
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?
3.4.24.87 von Willebrand factor + H2O Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens Q76LX8
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 astrocyte in cerebral corpora amylacea, that occur in aging brains and in patients with neurodegenerative conditions Homo sapiens
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3.4.24.87 blood platelet synthesizes and secreted ADAMTS13 Homo sapiens
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3.4.24.87 brain
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Homo sapiens
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3.4.24.87 corpus amylaceum in astrocytes of aging brains and patients with neurodegenerative conditions. Corporae amylaceae include glycosylated material, ubiquitin, and an assortment of proteins derived from neuronal cytoplasm. Many of these proteins are not specifically localized to neurons or astrocytes, some components of corpora amylacea, such as complement proteins, are most abundantly expressed outside the central nervous system. Corporae amylaceae can result from a conglomeration of interacting proteins from degenerating neurons and from extravasated blood elements released after transient breakdown of the blood-brain barrier Homo sapiens
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3.4.24.87 liver synthesizes and secreted ADAMTS13 Homo sapiens
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3.4.24.87 neuronal cell thrombospondin1 and ADAMTS13 form complexes together in cells and in direct protein binding assays Homo sapiens
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3.4.24.87 plasma the enzyme circulates in the blood Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 additional information thrombospondin1 and ADAMTS13 form complexes together in cells and in direct protein binding assays Homo sapiens ?
-
?
3.4.24.87 von Willebrand factor + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13
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Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.87 physiological function ADAMTS13 regulates physiological von Willebrand factor size Homo sapiens