Literature summary extracted from

Labussiere, M.; Idbaih, A.; Wang, X.W.; Marie, Y.; Boisselier, B.; Falet, C.; Paris, S.; Laffaire, J.; Carpentier, C.; Criniere, E.; Ducray, F.; El Hallani, S.; Mokhtari, K.; Hoang-Xuan, K.; Delattre, J.Y.; Sanson, M.
All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2 (2010), Neurology, 74, 1886-1890.

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.1.1.42	additional information	analysis of IDH1 mutations in chromosome 19, 1p19q, and prognostic impact in glioma patients, overview	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.1.1.42	cytosol	IDH1	Homo sapiens	5829	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.42	isocitrate + NADP+	Homo sapiens	-	2-oxoglutarate + NADPH + H+ + CO2	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.42	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.42	glioma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.42	isocitrate + NADP+	-	Homo sapiens	2-oxoglutarate + NADPH + H+ + CO2	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.42	cytosolic NADPH-dependent isocitrate dehydrogenase	-	Homo sapiens
1.1.1.42	IDH1	-	Homo sapiens
1.1.1.42	NADPH-dependent isocitrate dehydrogenase	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.42	NADP+	-	Homo sapiens
1.1.1.42	NADPH	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
1.1.1.42	additional information	all tumors with complete 1p19q codeletion are mutated in the IDH1 or IDH2 gene. Glioma patients having IDH1/IDH2 mutations show inproved median overall survival, different outcomes in WHO grade II and III gliomas according to the 1p19q and IDH1/IDH2 statusses, overview	Homo sapiens

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Release 2023.1 (January 2023)