EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.99.5 | 1,4,6-pregnatriene-3,20-dione | - |
Homo sapiens | |
1.3.99.5 | 1alpha,2alpha-epoxy-4,6-pregnadiene-3,20-dione | - |
Homo sapiens | |
1.3.99.5 | 20-hydroxyimino-1,4-pregnadiene-3-one | - |
Homo sapiens | |
1.3.99.5 | 20-hydroxyimino-4-pregnene-3-one | - |
Homo sapiens | |
1.3.99.5 | 20-hydroxyimino-5-oxo-A-nor-3,5-secopregnan-3-oic acid | - |
Homo sapiens | |
1.3.99.5 | 3beta-acetoxy-20-hydroxyimino-5-pregnene | - |
Homo sapiens | |
1.3.99.5 | 3beta-acetoxy-5-pregnen-20-one | - |
Homo sapiens | |
1.3.99.5 | 3beta-hydroxy-20-hydroxyiminopregnenolone | - |
Homo sapiens | |
1.3.99.5 | 4-aza-20-hydroxyimino-5-pregnene-3-one | an 4-azasteroid | Homo sapiens | |
1.3.99.5 | 5alpha,6alpha-epoxy-3beta-acetoxy-20-hydroxyiminopregnane | - |
Homo sapiens | |
1.3.99.5 | 5alpha,6alpha-epoxy-3beta-acetoxypregnan-20-one | - |
Homo sapiens | |
1.3.99.5 | 5alpha,6alpha-epoxy-3beta-hydroxypregnan-20-one | - |
Homo sapiens | |
1.3.99.5 | 5beta,6beta-epoxy-3beta-acetoxy-20-hydroxyiminopregnane | - |
Homo sapiens | |
1.3.99.5 | 5beta,6beta-epoxy-3beta-acetoxypregnan-20-one | - |
Homo sapiens | |
1.3.99.5 | finasteride | - |
Homo sapiens | |
1.3.99.5 | additional information | synthesis, enzyme inhibitory, and cell cytotoxicity of pregnan compounds, IC50 values for growth inhibition, overview | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.99.5 | dihydrotestosterone + NADP+ | Homo sapiens | the enzyme performs conversion of testosterone to dihydrotestosterone | testosterone + NADPH + H+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.99.5 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.99.5 | LNCaP cell | - |
Homo sapiens | - |
1.3.99.5 | PC-3 cell | - |
Homo sapiens | - |
1.3.99.5 | prostate | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.99.5 | dihydrotestosterone + NADP+ | - |
Homo sapiens | testosterone + NADPH + H+ | - |
r | |
1.3.99.5 | dihydrotestosterone + NADP+ | the enzyme performs conversion of testosterone to dihydrotestosterone | Homo sapiens | testosterone + NADPH + H+ | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.99.5 | 5alpha-reductase | - |
Homo sapiens |
1.3.99.5 | 5alpha-reductase II | - |
Homo sapiens |
1.3.99.5 | 5AR2 | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.3.99.5 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.3.99.5 | 5.5 | - |
assay at | Homo sapiens |