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Literature summary extracted from

  • Lee, J.; Jeong, E.; Choi, M.; Kim, S.; Park, J.; Song, S.; Park, J.; Bang, Y.; Kim, T.
    Inhibition of histone deacetylase 10 induces thioredoxin-interacting protein and causes accumulation of reactive oxygen species in SNU-620 human gastric cancer cells (2010), Mol. Cells, 30, 107-112.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 LAQ824 pan-HDAC inhibitor Homo sapiens
3.5.1.98 additional information HDAC10 is not inhibited by SK7068, MS275, and oxamflatin Homo sapiens
3.5.1.98 sodium butyrate pan-HDAC inhibitor Homo sapiens
3.5.1.98 suberoylanilide hydroxamic acid pan-HDAC inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.98 cytoplasm
-
 Homo sapiens 5737
-
3.5.1.98 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.98 alpha-tubulin + H2O Homo sapiens
-
 acetate + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 gastric cancer cell
-
 Homo sapiens
-
3.5.1.98 SNU-620 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.98 alpha-tubulin + H2O
-
 Homo sapiens acetate + ?
-
 ?
3.5.1.98 N6-lysine acetylated histone H3 + H2O
-
 Homo sapiens histone H3 + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC10
-
 Homo sapiens
3.5.1.98 histone deacetylase 10 a class IIb histone deacetylase Homo sapiens

General Information

EC Number General Information Comment Organism
3.5.1.98 malfunction knockdown of HDAC10 significantly increases the mRNA expression levels of thioredoxin-interacting protein and induces release of cytochrome c and activated apoptotic signaling molecules through accumulation of reactive oxygen species in SNU-620 human gastric cancer cells Homo sapiens
3.5.1.98 physiological function HDAC10 is involved in transcriptional downregulation of thioredoxin-interacting protein, leading to altered reactive oxygen species signaling in human gastric cancer cells Homo sapiens