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Literature summary extracted from

  • Kim, C.H.; Ramu, R.; Ahn, J.H.; Bae, M.A.; Cho, Y.S.
    Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes (2010), Mol. Cell. Biochem., 344, 91-98.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 bezafibrate 23% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 Clofibrate 18% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 fenofibrate 82% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 fenofibric acid 25% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 fenofibric acid cyclohexyl ester 54% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 fenofibric acid ethylester 85% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 fenofibric acid isobutylester 75% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 fenofibric acid isopropyl amide 54% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 fenofibric acid n-butylester 64% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 gemfibrozil 19% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 WY-14643 22% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 C2C12 cell differentiated into myotubes Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+
-
 Mus musculus cortisol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxysteroid dehydrogenase 1
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.146 0.0016
-
 fenofibrate 82% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 0.0031
-
 fenofibric acid isobutylester 75% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 0.0034
-
 fenofibric acid ethylester 85% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 0.0041
-
 fenofibric acid n-butylester 64% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 0.009
-
 fenofibric acid isopropyl amide 54% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus
1.1.1.146 0.0091
-
 fenofibric acid cyclohexyl ester 54% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication Mus musculus