EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.18 | gene iolG, expression analysis | Bacillus subtilis |
1.1.1.370 | expression in Escherichia coli as a C-terminally His6-tagged fusion protein | Bacillus subtilis |
1.1.1.371 | expression in Escherichia coli as a C-terminally His6-tagged fusion protein | Bacillus subtilis |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.1.18 | up | iolG expression is induced by myo-inositol, and less by scyllo-inositol | Bacillus subtilis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.370 | 0.019 | - |
NADH | pH 7.5, 37°C | Bacillus subtilis | |
1.1.1.370 | 0.15 | - |
NAD+ | pH 7.5, 37°C | Bacillus subtilis | |
1.1.1.370 | 2.85 | - |
2,4,6/3,5-pentahydroxycyclohexanone | pH 7.5, 37°C | Bacillus subtilis | |
1.1.1.370 | 2.85 | - |
scyllo-inosose | pH 7.5, 37°C | Bacillus subtilis | |
1.1.1.370 | 17.1 | - |
scyllo-Inositol | pH 7.5, 37°C | Bacillus subtilis | |
1.1.1.371 | 0.027 | - |
NADPH | pH 7.5, 37°C | Bacillus subtilis | |
1.1.1.371 | 0.096 | - |
NADP+ | pH 7.5, 37°C | Bacillus subtilis | |
1.1.1.371 | 1.68 | - |
2,4,6/3,5-pentahydroxycyclohexanone | pH 7.5, 37°C | Bacillus subtilis | |
1.1.1.371 | 34.3 | - |
scyllo-Inositol | pH 7.5, 37°C | Bacillus subtilis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.18 | 1-oxo-D-chiro-inositol + NADH + H+ | Bacillus subtilis | - |
D-chiro-inositol + NAD+ | - |
r | |
1.1.1.18 | 1-oxo-D-chiro-inositol + NADH + H+ | Bacillus subtilis 168 | - |
D-chiro-inositol + NAD+ | - |
r | |
1.1.1.18 | myo-inositol + NAD+ | Bacillus subtilis | - |
scyllo-inosose + NADH + H+ | - |
r | |
1.1.1.18 | myo-inositol + NAD+ | Bacillus subtilis 168 | - |
scyllo-inosose + NADH + H+ | - |
r | |
1.1.1.18 | pinitol + NADH + H+ | Bacillus subtilis | i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway | ? | - |
? | |
1.1.1.18 | pinitol + NADH + H+ | Bacillus subtilis 168 | i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway | ? | - |
? | |
1.1.1.370 | scyllo-inositol + NAD+ | Bacillus subtilis | the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA | 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ | - |
r | |
1.1.1.370 | scyllo-inositol + NAD+ | Bacillus subtilis 168 | the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA | 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.18 | Bacillus subtilis | - |
gene iolG | - |
1.1.1.18 | Bacillus subtilis 168 | - |
gene iolG | - |
1.1.1.370 | Bacillus subtilis | P40332 | - |
- |
1.1.1.370 | Bacillus subtilis 168 | P40332 | - |
- |
1.1.1.371 | Bacillus subtilis | O32223 | - |
- |
1.1.1.371 | Bacillus subtilis 168 | O32223 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.370 | - |
Bacillus subtilis |
1.1.1.371 | - |
Bacillus subtilis |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.370 | culture condition:scyllo-inositol-grown cell | - |
Bacillus subtilis | - |
1.1.1.371 | culture condition:scyllo-inositol-grown cell | - |
Bacillus subtilis | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.18 | 1-oxo-D-chiro-inositol + NADH + H+ | - |
Bacillus subtilis | D-chiro-inositol + NAD+ | - |
r | |
1.1.1.18 | 1-oxo-D-chiro-inositol + NADH + H+ | - |
Bacillus subtilis 168 | D-chiro-inositol + NAD+ | - |
r | |
1.1.1.18 | additional information | scyllo-inositol is no substrate for the enzyme, thus IolG does not act as a scyllo-inositol dehydrogenase | Bacillus subtilis | ? | - |
? | |
1.1.1.18 | additional information | scyllo-inositol is no substrate for the enzyme, thus IolG does not act as a scyllo-inositol dehydrogenase | Bacillus subtilis 168 | ? | - |
? | |
1.1.1.18 | myo-inositol + NAD+ | - |
Bacillus subtilis | scyllo-inosose + NADH + H+ | - |
r | |
1.1.1.18 | myo-inositol + NAD+ | - |
Bacillus subtilis 168 | scyllo-inosose + NADH + H+ | - |
r | |
1.1.1.18 | pinitol + NADH + H+ | i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway | Bacillus subtilis | ? | - |
? | |
1.1.1.18 | pinitol + NADH + H+ | i.e. 3-O-methyl-D-chiro-inositol | Bacillus subtilis | ? | - |
? | |
1.1.1.18 | pinitol + NADH + H+ | i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway | Bacillus subtilis 168 | ? | - |
? | |
1.1.1.18 | pinitol + NADH + H+ | i.e. 3-O-methyl-D-chiro-inositol | Bacillus subtilis 168 | ? | - |
? | |
1.1.1.370 | scyllo-inositol + NAD+ | no activity with NADP+ | Bacillus subtilis | 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ | 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose | r | |
1.1.1.370 | scyllo-inositol + NAD+ | the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA | Bacillus subtilis | 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ | - |
r | |
1.1.1.370 | scyllo-inositol + NAD+ | no activity with NADP+ | Bacillus subtilis 168 | 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ | 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose | r | |
1.1.1.370 | scyllo-inositol + NAD+ | the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA | Bacillus subtilis 168 | 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ | - |
r | |
1.1.1.370 | scyllo-inositol + NAD+ | - |
Bacillus subtilis | scyllo-inosose + NADH + H+ | - |
r | |
1.1.1.370 | scyllo-inositol + NAD+ | - |
Bacillus subtilis 168 | scyllo-inosose + NADH + H+ | - |
r | |
1.1.1.370 | scyllo-inosose + NADH + H+ | - |
Bacillus subtilis | scyllo-inositol + NAD+ | - |
r | |
1.1.1.370 | scyllo-inosose + NADH + H+ | - |
Bacillus subtilis 168 | scyllo-inositol + NAD+ | - |
r | |
1.1.1.371 | scyllo-inositol + NADP+ | no activity with NAD+ | Bacillus subtilis | 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+ | 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose | r | |
1.1.1.371 | scyllo-inositol + NADP+ | no activity with NAD+ | Bacillus subtilis 168 | 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+ | 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose | r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.18 | iolG | - |
Bacillus subtilis |
1.1.1.18 | MI dehydrogenase | - |
Bacillus subtilis |
1.1.1.370 | IolX | - |
Bacillus subtilis |
1.1.1.370 | yisS | formeryl, gene name | Bacillus subtilis |
1.1.1.371 | IolW | - |
Bacillus subtilis |
1.1.1.371 | yvaA | formerly, gene name | Bacillus subtilis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.370 | 37 | - |
assay at | Bacillus subtilis |
1.1.1.371 | 37 | - |
assay at | Bacillus subtilis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.370 | 7.5 | - |
assay at | Bacillus subtilis |
1.1.1.371 | 7.5 | - |
assay at | Bacillus subtilis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.18 | NAD+ | - |
Bacillus subtilis | |
1.1.1.18 | NADH | - |
Bacillus subtilis | |
1.1.1.370 | additional information | no activity with NADP+ | Bacillus subtilis | |
1.1.1.370 | NAD+ | - |
Bacillus subtilis | |
1.1.1.370 | NAD+ | no activity with NADP+ | Bacillus subtilis | |
1.1.1.370 | NADH | - |
Bacillus subtilis | |
1.1.1.371 | NADP+ | no activity with NAD+ | Bacillus subtilis |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.1.1.370 | Bacillus subtilis | induced during growth on scyllo-inositol | up |
1.1.1.370 | Bacillus subtilis | enzyme is prominently expressed when Bacillus subtilis is grown on medium containing scyllo-inositol | up |
1.1.1.371 | Bacillus subtilis | induced during growth on scyllo-inositol | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.18 | physiological function | the enzyme is involved in the myo-inositol catabolic pathway catalyzing the first step, overview | Bacillus subtilis |
1.1.1.370 | malfunction | inactivation of iolX impairs growth with scyllo-inositol as the carbon source | Bacillus subtilis |
1.1.1.370 | physiological function | the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA | Bacillus subtilis |