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Literature summary extracted from

  • Morinaga, T.; Ashida, H.; Yoshida, K.
    Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis (2010), Microbiology, 156, 1538-1546.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.18 gene iolG, expression analysis Bacillus subtilis
1.1.1.370 expression in Escherichia coli as a C-terminally His6-tagged fusion protein Bacillus subtilis
1.1.1.371 expression in Escherichia coli as a C-terminally His6-tagged fusion protein Bacillus subtilis

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.18 up iolG expression is induced by myo-inositol, and less by scyllo-inositol Bacillus subtilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.370 0.019
-
NADH pH 7.5, 37°C Bacillus subtilis
1.1.1.370 0.15
-
NAD+ pH 7.5, 37°C Bacillus subtilis
1.1.1.370 2.85
-
2,4,6/3,5-pentahydroxycyclohexanone pH 7.5, 37°C Bacillus subtilis
1.1.1.370 2.85
-
scyllo-inosose pH 7.5, 37°C Bacillus subtilis
1.1.1.370 17.1
-
scyllo-Inositol pH 7.5, 37°C Bacillus subtilis
1.1.1.371 0.027
-
NADPH pH 7.5, 37°C Bacillus subtilis
1.1.1.371 0.096
-
NADP+ pH 7.5, 37°C Bacillus subtilis
1.1.1.371 1.68
-
2,4,6/3,5-pentahydroxycyclohexanone pH 7.5, 37°C Bacillus subtilis
1.1.1.371 34.3
-
scyllo-Inositol pH 7.5, 37°C Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.18 1-oxo-D-chiro-inositol + NADH + H+ Bacillus subtilis
-
D-chiro-inositol + NAD+
-
r
1.1.1.18 1-oxo-D-chiro-inositol + NADH + H+ Bacillus subtilis 168
-
D-chiro-inositol + NAD+
-
r
1.1.1.18 myo-inositol + NAD+ Bacillus subtilis
-
scyllo-inosose + NADH + H+
-
r
1.1.1.18 myo-inositol + NAD+ Bacillus subtilis 168
-
scyllo-inosose + NADH + H+
-
r
1.1.1.18 pinitol + NADH + H+ Bacillus subtilis i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway ?
-
?
1.1.1.18 pinitol + NADH + H+ Bacillus subtilis 168 i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway ?
-
?
1.1.1.370 scyllo-inositol + NAD+ Bacillus subtilis the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
r
1.1.1.370 scyllo-inositol + NAD+ Bacillus subtilis 168 the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.18 Bacillus subtilis
-
gene iolG
-
1.1.1.18 Bacillus subtilis 168
-
gene iolG
-
1.1.1.370 Bacillus subtilis P40332
-
-
1.1.1.370 Bacillus subtilis 168 P40332
-
-
1.1.1.371 Bacillus subtilis O32223
-
-
1.1.1.371 Bacillus subtilis 168 O32223
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.370
-
Bacillus subtilis
1.1.1.371
-
Bacillus subtilis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.370 culture condition:scyllo-inositol-grown cell
-
Bacillus subtilis
-
1.1.1.371 culture condition:scyllo-inositol-grown cell
-
Bacillus subtilis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.18 1-oxo-D-chiro-inositol + NADH + H+
-
Bacillus subtilis D-chiro-inositol + NAD+
-
r
1.1.1.18 1-oxo-D-chiro-inositol + NADH + H+
-
Bacillus subtilis 168 D-chiro-inositol + NAD+
-
r
1.1.1.18 additional information scyllo-inositol is no substrate for the enzyme, thus IolG does not act as a scyllo-inositol dehydrogenase Bacillus subtilis ?
-
?
1.1.1.18 additional information scyllo-inositol is no substrate for the enzyme, thus IolG does not act as a scyllo-inositol dehydrogenase Bacillus subtilis 168 ?
-
?
1.1.1.18 myo-inositol + NAD+
-
Bacillus subtilis scyllo-inosose + NADH + H+
-
r
1.1.1.18 myo-inositol + NAD+
-
Bacillus subtilis 168 scyllo-inosose + NADH + H+
-
r
1.1.1.18 pinitol + NADH + H+ i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway Bacillus subtilis ?
-
?
1.1.1.18 pinitol + NADH + H+ i.e. 3-O-methyl-D-chiro-inositol Bacillus subtilis ?
-
?
1.1.1.18 pinitol + NADH + H+ i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway Bacillus subtilis 168 ?
-
?
1.1.1.18 pinitol + NADH + H+ i.e. 3-O-methyl-D-chiro-inositol Bacillus subtilis 168 ?
-
?
1.1.1.370 scyllo-inositol + NAD+ no activity with NADP+ Bacillus subtilis 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose r
1.1.1.370 scyllo-inositol + NAD+ the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA Bacillus subtilis 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
r
1.1.1.370 scyllo-inositol + NAD+ no activity with NADP+ Bacillus subtilis 168 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose r
1.1.1.370 scyllo-inositol + NAD+ the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA Bacillus subtilis 168 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
-
r
1.1.1.370 scyllo-inositol + NAD+
-
Bacillus subtilis scyllo-inosose + NADH + H+
-
r
1.1.1.370 scyllo-inositol + NAD+
-
Bacillus subtilis 168 scyllo-inosose + NADH + H+
-
r
1.1.1.370 scyllo-inosose + NADH + H+
-
Bacillus subtilis scyllo-inositol + NAD+
-
r
1.1.1.370 scyllo-inosose + NADH + H+
-
Bacillus subtilis 168 scyllo-inositol + NAD+
-
r
1.1.1.371 scyllo-inositol + NADP+ no activity with NAD+ Bacillus subtilis 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+ 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose r
1.1.1.371 scyllo-inositol + NADP+ no activity with NAD+ Bacillus subtilis 168 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+ 2,4,6/3,5-pentahydroxycyclohexanone i.e. (2R,3S,4s,5R,6S)-2,3,4,5,6-pentahydroxycyclohexanone i.e. scyllo-inosose r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.18 iolG
-
Bacillus subtilis
1.1.1.18 MI dehydrogenase
-
Bacillus subtilis
1.1.1.370 IolX
-
Bacillus subtilis
1.1.1.370 yisS formeryl, gene name Bacillus subtilis
1.1.1.371 IolW
-
Bacillus subtilis
1.1.1.371 yvaA formerly, gene name Bacillus subtilis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.370 37
-
assay at Bacillus subtilis
1.1.1.371 37
-
assay at Bacillus subtilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.370 7.5
-
assay at Bacillus subtilis
1.1.1.371 7.5
-
assay at Bacillus subtilis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.18 NAD+
-
Bacillus subtilis
1.1.1.18 NADH
-
Bacillus subtilis
1.1.1.370 additional information no activity with NADP+ Bacillus subtilis
1.1.1.370 NAD+
-
Bacillus subtilis
1.1.1.370 NAD+ no activity with NADP+ Bacillus subtilis
1.1.1.370 NADH
-
Bacillus subtilis
1.1.1.371 NADP+ no activity with NAD+ Bacillus subtilis

Expression

EC Number Organism Comment Expression
1.1.1.370 Bacillus subtilis induced during growth on scyllo-inositol up
1.1.1.370 Bacillus subtilis enzyme is prominently expressed when Bacillus subtilis is grown on medium containing scyllo-inositol up
1.1.1.371 Bacillus subtilis induced during growth on scyllo-inositol up

General Information

EC Number General Information Comment Organism
1.1.1.18 physiological function the enzyme is involved in the myo-inositol catabolic pathway catalyzing the first step, overview Bacillus subtilis
1.1.1.370 malfunction inactivation of iolX impairs growth with scyllo-inositol as the carbon source Bacillus subtilis
1.1.1.370 physiological function the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA Bacillus subtilis