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Literature summary extracted from
- Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond (2011), Methods Mol. Biol., 677, 269-280.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.13.11.52 | cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.52 | 5-hydroxy-L-tryptophan + O2 | Homo sapiens | - |
N-formyl-5-hydroxy-L-kynurenine | - |
? |  |
| 1.13.11.52 | D-tryptophan + O2 | Homo sapiens | - |
N-formyl-D-kynurenine | - |
? | |
| 1.13.11.52 | L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? | |
| 1.13.11.52 | serotonin + O2 | Homo sapiens | - |
? | - |
? | |
| 1.13.11.52 | tryptamine + O2 | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.52 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.52 | dendritic cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.52 | 5-hydroxy-L-tryptophan + O2 | - |
Homo sapiens | N-formyl-5-hydroxy-L-kynurenine | - |
? | |
| 1.13.11.52 | D-tryptophan + O2 | - |
Homo sapiens | N-formyl-D-kynurenine | - |
? | |
| 1.13.11.52 | L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? | |
| 1.13.11.52 | serotonin + O2 | - |
Homo sapiens | ? | - |
? | |
| 1.13.11.52 | tryptamine + O2 | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.13.11.52 | monomer | 1 * 42000-45000 | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.11.52 | IDO | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.52 | heme | - |
Homo sapiens | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.13.11.52 | metabolism | IDO is the first and rate-limiting enzyme in the kynurenine pathway | Homo sapiens |
| 1.13.11.52 | physiological function | IDO is involved in the maintenance of immune tolerance at the maternal-fetal interface | Homo sapiens |
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Release 2023.1 (January 2023)
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