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Literature summary extracted from

  • Varadi, K.; Rottensteiner, H.; Vejda, S.; Weber, A.; Muchitsch, E.M.; Turecek, P.L.; Ehrlich, H.J.; Scheiflinger, F.; Schwarz, H.P.
    Species-dependent variability of ADAMTS13-mediated proteolysis of human recombinant von Willebrand factor (2009), J. Thromb. Haemost., 7, 1134-1142.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 extracellular
-
Cavia porcellus
-
-
3.4.24.87 extracellular
-
Mus musculus
-
-
3.4.24.87 extracellular
-
Homo sapiens
-
-
3.4.24.87 extracellular
-
Rattus norvegicus
-
-
3.4.24.87 extracellular
-
Sus scrofa
-
-
3.4.24.87 extracellular
-
Oryctolagus cuniculus
-
-
3.4.24.87 extracellular
-
Canis lupus familiaris
-
-
3.4.24.87 extracellular
-
Macaca fascicularis
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.87 Ba2+ activates Cavia porcellus
3.4.24.87 Ba2+ activates Mus musculus
3.4.24.87 Ba2+ activates Homo sapiens
3.4.24.87 Ba2+ activates Rattus norvegicus
3.4.24.87 Ba2+ activates Sus scrofa
3.4.24.87 Ba2+ activates Oryctolagus cuniculus
3.4.24.87 Ba2+ activates Canis lupus familiaris
3.4.24.87 Ba2+ activates Macaca fascicularis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Cavia porcellus ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O Mus musculus ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O Homo sapiens ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O Rattus norvegicus ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O Sus scrofa ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O Oryctolagus cuniculus ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O Canis lupus familiaris ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O Macaca fascicularis ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Canis lupus familiaris
-
beagle dogs
-
3.4.24.87 Cavia porcellus
-
Dunkin Hartley guinea pigs
-
3.4.24.87 Homo sapiens
-
-
-
3.4.24.87 Macaca fascicularis
-
cynomolgus monkey
-
3.4.24.87 Mus musculus
-
wild-type strain C57BL/6J mice, the isogenic von Willebrand factor-deficient strain 129x1/SvJ, and the ADAMTS13-deficient gene knock-out strain CAST/EiJ
-
3.4.24.87 Oryctolagus cuniculus
-
New Zealand white rabbits
-
3.4.24.87 Rattus norvegicus
-
Sprague-Dawley rats
-
3.4.24.87 Sus scrofa
-
Yorkshire strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 plasma
-
Cavia porcellus
-
3.4.24.87 plasma
-
Mus musculus
-
3.4.24.87 plasma
-
Homo sapiens
-
3.4.24.87 plasma
-
Rattus norvegicus
-
3.4.24.87 plasma
-
Sus scrofa
-
3.4.24.87 plasma
-
Oryctolagus cuniculus
-
3.4.24.87 plasma
-
Canis lupus familiaris
-
3.4.24.87 plasma
-
Macaca fascicularis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Cavia porcellus ?
-
?
3.4.24.87 additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Homo sapiens ?
-
?
3.4.24.87 additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Rattus norvegicus ?
-
?
3.4.24.87 additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Sus scrofa ?
-
?
3.4.24.87 additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Oryctolagus cuniculus ?
-
?
3.4.24.87 additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Canis lupus familiaris ?
-
?
3.4.24.87 additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Macaca fascicularis ?
-
?
3.4.24.87 additional information no activity in von Willebrand factor-deficient or ADAMTS13-deficient mice with the recombinant substrate of human origin. Differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Mus musculus ?
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Cavia porcellus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Mus musculus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Homo sapiens von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Rattus norvegicus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Sus scrofa von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Oryctolagus cuniculus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Canis lupus familiaris von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Macaca fascicularis von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Macaca fascicularis von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Comparison of the activity with human recombinan substrate in vitro with enzymes from other mammal enzymes, overview Homo sapiens von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The guinea pig ADAMTS13 shows no activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Cavia porcellus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The rabbit ADAMTS13 shows activity similar to the human ADAMTS13 with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Oryctolagus cuniculus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The rat ADAMTS13 shows no activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Rattus norvegicus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The wild-type mouse ADAMTS13 shows no activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Mus musculus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Very low activity with recombinant human substrate in vitro, comparison to other mammal enzymes, overview Sus scrofa von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Very low activity with recombinant human substrate in vitro, comparison to other mammal enzymes, overview Canis lupus familiaris von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13
-
Cavia porcellus
3.4.24.87 ADAMTS13
-
Mus musculus
3.4.24.87 ADAMTS13
-
Homo sapiens
3.4.24.87 ADAMTS13
-
Rattus norvegicus
3.4.24.87 ADAMTS13
-
Sus scrofa
3.4.24.87 ADAMTS13
-
Oryctolagus cuniculus
3.4.24.87 ADAMTS13
-
Canis lupus familiaris
3.4.24.87 ADAMTS13
-
Macaca fascicularis
3.4.24.87 plasma metalloprotease ADAMTS13
-
Cavia porcellus
3.4.24.87 plasma metalloprotease ADAMTS13
-
Mus musculus
3.4.24.87 plasma metalloprotease ADAMTS13
-
Homo sapiens
3.4.24.87 plasma metalloprotease ADAMTS13
-
Rattus norvegicus
3.4.24.87 plasma metalloprotease ADAMTS13
-
Sus scrofa
3.4.24.87 plasma metalloprotease ADAMTS13
-
Oryctolagus cuniculus
3.4.24.87 plasma metalloprotease ADAMTS13
-
Canis lupus familiaris
3.4.24.87 plasma metalloprotease ADAMTS13
-
Macaca fascicularis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.87 37
-
assay at Cavia porcellus
3.4.24.87 37
-
assay at Mus musculus
3.4.24.87 37
-
assay at Homo sapiens
3.4.24.87 37
-
assay at Rattus norvegicus
3.4.24.87 37
-
assay at Sus scrofa
3.4.24.87 37
-
assay at Oryctolagus cuniculus
3.4.24.87 37
-
assay at Canis lupus familiaris
3.4.24.87 37
-
assay at Macaca fascicularis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.87 8
-
assay at Cavia porcellus
3.4.24.87 8
-
assay at Mus musculus
3.4.24.87 8
-
assay at Homo sapiens
3.4.24.87 8
-
assay at Rattus norvegicus
3.4.24.87 8
-
assay at Sus scrofa
3.4.24.87 8
-
assay at Oryctolagus cuniculus
3.4.24.87 8
-
assay at Canis lupus familiaris
3.4.24.87 8
-
assay at Macaca fascicularis