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Literature summary extracted from

  • Liao, W.L.; Heo, G.Y.; Dodder, N.G.; Reem, R.E.; Mast, N.; Huang, S.; Dipatre, P.L.; Turko, I.V.; Pikuleva, I.A.
    Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain (2011), J. Proteome Res., 10, 241-248.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.25 expressed in Escherichia coli GC5 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.25 membrane associated Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Homo sapiens
-
 (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.25 Homo sapiens
-
-
-
1.14.14.25 Homo sapiens Q9Y6A2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.25 brain
-
 Homo sapiens
-
1.14.14.25 brain quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview Homo sapiens
-
1.14.14.25 additional information quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview Homo sapiens
-
1.14.14.25 neuron
-
 Homo sapiens
-
1.14.14.25 retina
-
 Homo sapiens
-
1.14.14.25 retina quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.25 CYP46A1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.25 NADPH
-
 Homo sapiens