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Literature summary extracted from

  • Ren, J.; Sun, L.; Wu, J.; Zhao, S.; Wang, C.; Wang, Y.; Ji, K.; Leng, P.
    Cloning and expression analysis of cDNAs for ABA 8'-hydroxylase during sweet cherry fruit maturation and under stress conditions (2010), J. Plant Physiol., 167, 1486-1493.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.137 cDNA CYP707A1, DNA and amino acid sequence determination and analysis, phylogenetic tree Prunus avium
1.14.14.137 cDNA CYP707A2, DNA and amino acid sequence determination and analysis, phylogenetic tree Prunus avium
1.14.14.137 cDNA CYP707A3, DNA and amino acid sequence determination and analysis, phylogenetic tree Prunus avium
1.14.14.137 cDNA CYP707A4, DNA and amino acid sequence determination and analysis, phylogenetic tree Prunus avium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.137 (+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2 Prunus avium
-
 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.137 (+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2 Prunus avium Hongdeng
-
 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.137 Prunus avium E3TB04 CYP707A1; four cDNAs CYP707A1-CYP707A4 encoding ABA 8'-hydroxylase
-
1.14.14.137 Prunus avium E3TB05 CYP707A2; four cDNAs CYP707A1-CYP707A4 encoding ABA 8'-hydroxylase
-
1.14.14.137 Prunus avium E3TB06 CYP707A4; four cDNAs CYP707A1-CYP707A4 encoding ABA 8'-hydroxylase
-
1.14.14.137 Prunus avium E3TB07 CYP707A3; four cDNAs CYP707A1-CYP707A4 encoding ABA 8'-hydroxylase
-
1.14.14.137 Prunus avium Hongdeng E3TB04 CYP707A1; four cDNAs CYP707A1-CYP707A4 encoding ABA 8'-hydroxylase
-
1.14.14.137 Prunus avium Hongdeng E3TB05 CYP707A2; four cDNAs CYP707A1-CYP707A4 encoding ABA 8'-hydroxylase
-
1.14.14.137 Prunus avium Hongdeng E3TB06 CYP707A4; four cDNAs CYP707A1-CYP707A4 encoding ABA 8'-hydroxylase
-
1.14.14.137 Prunus avium Hongdeng E3TB07 CYP707A3; four cDNAs CYP707A1-CYP707A4 encoding ABA 8'-hydroxylase
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.137 fruit all four CYP707As are expressed at varying intensities throughout sweet cherry fruit development, expression pattern of CYP707A1, overview Prunus avium
-
1.14.14.137 fruit all four CYP707As are expressed at varying intensities throughout sweet cherry fruit development, expression pattern of CYP707A2, overview Prunus avium
-
1.14.14.137 fruit all four CYP707As are expressed at varying intensities throughout sweet cherry fruit development, expression pattern of CYP707A3, overview Prunus avium
-
1.14.14.137 fruit all four CYP707As are expressed at varying intensities throughout sweet cherry fruit development, expression pattern of CYP707A4, overview Prunus avium
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.137 (+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2
-
 Prunus avium 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.137 (+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2
-
 Prunus avium Hongdeng 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.137 ABA 8'-hydroxylase
-
 Prunus avium
1.14.14.137 CYP707A1
-
 Prunus avium
1.14.14.137 CYP707A2
-
 Prunus avium
1.14.14.137 CYP707A3
-
 Prunus avium
1.14.14.137 CYP707A4
-
 Prunus avium

Expression

EC Number Organism Comment Expression
1.14.14.137 Prunus avium application of abscisic acid suppresses the expression of CYP707A2. Expression of CYP707A2 is not significantly altered in dehydrated fruits compared to control fruits down
1.14.14.137 Prunus avium application of abscisic acid induces the expression of CYP707A1. Expression of CYP707A1 is strongly increased by water stress up
1.14.14.137 Prunus avium application of abscisic acid induces the expression of CYP707A2. Expression of CYP707A2 is not significantly altered in dehydrated fruits compared to control fruits up
1.14.14.137 Prunus avium application of abscisic acid induces the expression of CYP707A3. Expression of CYP707A3 is strongly increased by water stress up

General Information

EC Number General Information Comment Organism
1.14.14.137 metabolism ABA 8'-hydroxylase is a key enzyme in the oxidative catabolism of abscisic acid. Endogenous abscisic acid content is modulated by a dynamic balance between biosynthesis and catabolism, which are regulated by NCED1 and CYP707As transcripts, respectively, during fruit maturation and under stress conditions, overview Prunus avium
1.14.14.137 metabolism ABA 8'-hydroxylase is a key enzyme in the oxidative catabolism of abscisic acid. Endogenous abscisic acid content is modulated by a dynamic balance between biosynthesis and catabolism, which are regulated by NCED1 and CYP707As transcripts, respectively, during fruit maturation and under stress conditions, overview. Application of abscisic acid induces the expression of CYP707A1-CYP707A3 as well as PacNCED1, encoding 9-cis-epoxycarotenoid dioxygenase, but downregulates the CYP707A4 transcript level. Expressions of CYP707A1 and CYP707A3 are strongly increased by water stress, while no significant differences in CYP707A2 and CYP707A4 expression are observed between dehydrated and control fruits Prunus avium
1.14.14.137 physiological function all four CYP707As are expressed at varying intensities throughout fruit development and appear to play overlapping roles in abscisic acid catabolism throughout sweet cherry fruit development Prunus avium