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Literature summary extracted from

  • Naidu, P.S.; Kinsey, S.G.; Guo, T.L.; Cravatt, B.F.; Lichtman, A.H.
    Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase (2010), J. Pharmacol. Exp. Ther., 334, 182-190.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.5.1.99 drug development FAAH is an attractive target for treating pain Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.99 cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester i.e. URB597, attenuates the development of lipopolysaccharide-induced paw edema and reverses lipopolysaccharide-induced hyperalgesia through the respective CB2 and CB1 mechanisms of action. The inhibition is not affected by capsazepine, a transient receptor potential vanilloid type 1 antagonist Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.99 anandamide + H2O Mus musculus i.e. N-arachidonoylethanolamine arachidonic acid + ethanolamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.99 Mus musculus
-
 male C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.99 neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.99 anandamide + H2O i.e. N-arachidonoylethanolamine Mus musculus arachidonic acid + ethanolamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.99 FAAH
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.5.1.99 physiological function FAAH is the chief catabolic enzyme regulating the endogenous cannabinoid N-arachidonoylethanolamine, i.e. anandamide Mus musculus