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Literature summary extracted from

  • Lash, T.D.; Mani, U.N.; Keck, A.S.; Jones, M.A.
    Normal and abnormal heme biosynthesis. 6. Synthesis and metabolism of a series of monovinylporphyrinogens related to harderoporphyrinogen. Further insights into the oxidative decarboxylation of porphyrinogen substrates by coproporphyrinogen oxidase (2010), J. Org. Chem., 75, 3183-3192.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.3.3 crystal structure analysis Homo sapiens
1.3.3.3 crystal structure analysis Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.3 mitochondrion
-
 Homo sapiens 5739
-
1.3.3.3 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ Gallus gallus
-
 protoporphyrinogen IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ Homo sapiens
-
 protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ Saccharomyces cerevisiae
-
 protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Gallus gallus
-
-
-
1.3.3.3 Homo sapiens
-
-
-
1.3.3.3 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 erythrocyte
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 17-ethyl harderoporphyrinogen-III + O2 + 2 H+
-
 Gallus gallus ?
-
 ?
1.3.3.3 17-ethylharderoporphyrinogen-III + O2 + 2 H+
-
 Homo sapiens 17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 17-ethylharderoporphyrinogen-III + O2 + 2 H+
-
 Saccharomyces cerevisiae 17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen III + O2 + 2 H+
-
 Gallus gallus protoporphyrinogen IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen III + O2 + 2 H+
-
 Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen III + O2 + 2 H+
-
 Saccharomyces cerevisiae protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ two oxidative decarboxylations sequentially to give a monovinylporphyrinogen intermediate Regiospecific generation of harderoporphyrinogen as an intermediate by first converting the A ring side chain to a vinyl unit. Type isomers of coproporphyrinogen, overview Saccharomyces cerevisiae protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ two oxidative decarboxylations sequentially to give a monovinylporphyrinogen intermediate. Regiospecific generation of harderoporphyrinogen as an intermediate by first converting the A ring side chain to a vinyl unit. Type isomers of coproporphyrinogen, overview Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 harderoporphyrinogen-III + O2 + 2 H+
-
 Gallus gallus ?
-
 ?
1.3.3.3 harderoporphyrinogen-IV + O2 + 2 H+
-
 Gallus gallus ?
-
 ?
1.3.3.3 harderoporphyrinogen-VII + O2 + 2 H+ a monovinyl intermediate in the metabolism of coproporphyrinogen-IV Gallus gallus ?
-
 ?
1.3.3.3 harderoporphyrinogen-VII + O2 + 2 H+
-
 Homo sapiens ? + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 harderoporphyrinogen-VII + O2 + 2 H+
-
 Saccharomyces cerevisiae ? + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 isoharderoporphyrinogen + O2 + 2 H+ very low activity Gallus gallus ?
-
 ?
1.3.3.3 isoharderoporphyrinogen + O2 + 2 H+
-
 Homo sapiens ? + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 isoharderoporphyrinogen + O2 + 2 H+
-
 Saccharomyces cerevisiae ? + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 additional information a nonnatural type I isomer of harderoporphyrinogen is also a substrate of CPO, no activity with 13-ethyl harderoporphyrinogen-III, substrate specificity with vinylic porphyrinogen derivatives, harderoporphyrinogen derivatives, and reaction mechanism, detailed overview Gallus gallus ?
-
 ?
1.3.3.3 additional information the 17-ethyl analogue of harderoporphyrinogen-III, but not its 13-ethyl isomer, is an excellent substrate for the enzyme in accord with a proposed model for the active site of the enzyme. Harderoporphyrinogen-VII, the monovinyl intermediate in the metabolism of coproporphyrinogen-IV, is an equally good substrate Homo sapiens ?
-
 ?
1.3.3.3 additional information the 17-ethyl analogue of harderoporphyrinogen-III, but not its 13-ethyl isomer, is an excellent substrate for the enzyme in accord with a proposed model for the active site of the enzyme. Harderoporphyrinogen-VII, the monovinyl intermediate in the metabolism of coproporphyrinogen-IV, is an equally good substrate Saccharomyces cerevisiae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 CPO
-
 Gallus gallus
1.3.3.3 CPO
-
 Homo sapiens
1.3.3.3 CPO
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
1.3.3.3 metabolism porphyrinogen derivative metabolis pathway, overview Gallus gallus
1.3.3.3 additional information model for the active site, overview Gallus gallus
1.3.3.3 additional information active-site models for substrate binding by coproporphyrinogen oxidase, overview. The invariant amino acids aspartate 400, arginine 262, and arginine 401 are essential for significant catalytic activity Homo sapiens
1.3.3.3 additional information active-site models for substrate binding by coproporphyrinogen oxidase, overview. The invariant amino acids aspartate 400, arginine 262, and arginine 401 are essential for significant catalytic activity Saccharomyces cerevisiae