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Literature summary extracted from

  • Benoit, C.E.; Bastianetto, S.; Brouillette, J.; Tse, Y.; Boutin, J.A.; Delagrange, P.; Wong, T.; Sarret, P.; Quirion, R.
    Loss of quinone reductase 2 function selectively facilitates learning behaviors (2010), J. Neurosci., 30, 12690-12700.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.10.5.1 medicine QR2 inhibitors possibly represent a therapeutic strategy toward the treatment of learning deficits especially observed in the aged brain Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.10.5.1 expressed in Sf9 insect cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.5.1 S26695 selective inhibitor of QR2 Rattus norvegicus
1.10.5.1 S29434 selective inhibitor of QR2 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.10.5.1 cytosol
-
Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.10.5.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.5.1
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.10.5.1 brain cortex
-
Rattus norvegicus
-
1.10.5.1 embryonic hippocampal cell line
-
Rattus norvegicus
-
1.10.5.1 hippocampus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.5.1 N-benzyldihydronicotinamide + menadione
-
Rattus norvegicus N-benzylnicotamide + menadiol
-
?

Synonyms

EC Number Synonyms Comment Organism
1.10.5.1 QR2
-
Rattus norvegicus
1.10.5.1 quinone reductase 2
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.10.5.1 FAD
-
Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.10.5.1 malfunction adult QR2 knock-out mice demonstrate enhanced learning abilities in various tasks, including Morris water maze, object recognition, and rotarod performance test, while other behaviors related to anxiety (elevated plus maze), depression (forced swim), and schizophrenia (prepulse inhibition) are not affected in QR2-deficient mice. QR2 inhibition protects hippocampal cells against menadione-induced toxicity and serum deprivation and can reverse cognitive deficits Rattus norvegicus
1.10.5.1 physiological function QR2 plays a role in cognitive behaviors Rattus norvegicus