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Literature summary extracted from

  • Khan, K.M.; Wadood, A.; Ali, M.; Zia-Ullah, M.; Ul-Haq, Z.; Lodhi, M.A.; Khan, M.; Perveen, S.; Choudhary, M.I.
    Identification of potent urease inhibitors via ligand- and structure-based virtual screening and in vitro assays (2010), J. Mol. Graph. Model., 28, 792-798.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.5 Acetohydroxamic acid
-
 Canavalia ensiformis
3.5.1.5 Acetohydroxamic acid
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-amino-4-methylthiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-amino-4-methylthiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-[(methoxycarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-[(methoxycarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-[bis(chlorocarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-[bis(chlorocarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-[[(chloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-[[(chloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-[[(chloromethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-[[(chloromethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-[[(dichloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-[[(dichloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Sporosarcina pasteurii
3.5.1.5 methyl 2-[[(methylsulfanyl)carbonothioyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Canavalia ensiformis
3.5.1.5 methyl 2-[[(methylsulfanyl)carbonothioyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
-
 Sporosarcina pasteurii

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.5 Canavalia ensiformis
-
-
-
3.5.1.5 Sporosarcina pasteurii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.5 urea + H2O
-
 Canavalia ensiformis CO2 + NH3
-
 ?
3.5.1.5 urea + H2O
-
 Sporosarcina pasteurii CO2 + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.5 urease
-
 Canavalia ensiformis
3.5.1.5 urease
-
 Sporosarcina pasteurii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.5 30
-
 assay at Canavalia ensiformis
3.5.1.5 30
-
 assay at Sporosarcina pasteurii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.5 8.2
-
 assay at Canavalia ensiformis
3.5.1.5 8.2
-
 assay at Sporosarcina pasteurii

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.5 0.00077
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-[bis(chlorocarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.00083
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-amino-4-methylthiophene-3-carboxylate
3.5.1.5 0.00213
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
3.5.1.5 0.00281
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-amino-4-methylthiophene-3-carboxylate
3.5.1.5 0.00299
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-[bis(chlorocarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.00504
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
3.5.1.5 0.00534
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.00635
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-[[(chloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.0093
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.01054
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-[[(methylsulfanyl)carbonothioyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.01107
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
3.5.1.5 0.01242
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-[[(chloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.01321
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-[[(dichloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.01369
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-[[(methylsulfanyl)carbonothioyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.01658
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
3.5.1.5 0.01832
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-[(methoxycarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.01945
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-[[(dichloromethoxy)carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.02221
-
 pH 8.2, 30°C Sporosarcina pasteurii Acetohydroxamic acid
3.5.1.5 0.0241
-
 pH 8.2, 30°C Canavalia ensiformis Acetohydroxamic acid
3.5.1.5 0.02495
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-[(methoxycarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
3.5.1.5 0.0271
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-[[(chloromethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
3.5.1.5 0.02801
-
 pH 8.2, 30°C Sporosarcina pasteurii methyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
3.5.1.5 0.02908
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-[[(chloromethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
3.5.1.5 0.03184
-
 pH 8.2, 30°C Canavalia ensiformis methyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate