EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.1 | additional information | zVAD, a pancaspase inhibitor, and TcdB, a caspase 3 inductor, induces membrane flip-flop in H9c2 cells, overview | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.6.2.1 | plasma membrane | - |
Rattus norvegicus | 5886 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.1 | Mg2+ | - |
Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.1 | ATP + H2O + phosphatidylserine/in | Rattus norvegicus | leading to reversible exposure on in the outer plasma membrane leaflet on the cell surface of cardiomyocytes by a flip-flop mechanism | ADP + phosphate + phosphatidylserine/out | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.1 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
7.6.2.1 | cardiomyoblast | - |
Rattus norvegicus | - |
7.6.2.1 | cardiomyocyte | adult ventricular | Rattus norvegicus | - |
7.6.2.1 | H9c2 cell | neonatal rat cardiomyoblasts | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.1 | ATP + H2O + phosphatidylserine/in | - |
Rattus norvegicus | ADP + phosphate + phosphatidylserine/out | - |
? | |
7.6.2.1 | ATP + H2O + phosphatidylserine/in | leading to reversible exposure on in the outer plasma membrane leaflet on the cell surface of cardiomyocytes by a flip-flop mechanism | Rattus norvegicus | ADP + phosphate + phosphatidylserine/out | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.6.2.1 | flippase | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
7.6.2.1 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
7.6.2.1 | 7 | - |
assay at | Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
7.6.2.1 | physiological function | flippase selectively transports phosphatidylserine from the outer to the inner plasma membrane layer and thereby maintains transbilayer phospholipid asymmetry. Possible role for Rho 34 and downstream effector Rho-associated kinase in the process of reversible phosphatidylserine exposure, involving the flippase and apoptosis in cardiomyocytes. Regulation of Rho-ROCK signaling and effect of inhibition of Rho-ROCK signaling on flippase activity, overview. Inhibition of Rho-ROCK signaling, by Y27632 or H1152, induces apoptotic and non-apoptotic phosphatidylserine exposure in cardiomyocytes via inhibition of flippase | Rattus norvegicus |