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Literature summary extracted from

  • Jansen, T.; Hortmann, M.; Oelze, M.; Opitz, B.; Steven, S.; Schell, R.; Knorr, M.; Karbach, S.; Schuhmacher, S.; Wenzel, P.; Muenzel, T.; Daiber, A.
    Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin (2010), J. Mol. Cell. Cardiol., 49, 186-195.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.24 additional information since no specific inhibitors for BVR are known, siRNA is used to silence the BVR gene in primary endothelial cells and accordingly suppress its activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.24 additional information since no specific inhibitors for BVR are known, siRNA is used to silence the BVR gene in primary endothelial cells and accordingly suppress its activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.24 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 bilirubin + NAD+ Homo sapiens
-
 biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NADP+ Homo sapiens
-
 biliverdin + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.24 endothelial cell
-
 Homo sapiens
-
1.3.1.24 neutrophil
-
 Homo sapiens
-
1.3.1.24 umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 bilirubin + NAD+
-
 Homo sapiens biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 BVR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 NAD+
-
 Homo sapiens
1.3.1.24 NADH
-
 Homo sapiens
1.3.1.24 NADP+
-
 Homo sapiens
1.3.1.24 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.3.1.24 metabolism BVR is part of the heme oxygenase protection system, overview Homo sapiens
1.3.1.24 additional information bilirubin is a superior antioxidant in isolated mitochondria and neutrophils as compared to biliverdin, overview. XO-derived superoxide is decreased in a concentration-dependent fashion by bilirubin whereas biliverdin has no inhibitory effect and even significantly increases the signal pointing towards pro-oxidative effects Homo sapiens
1.3.1.24 physiological function the significant effect of biliverdin on decrease in extracellular oxidative stress in BVR-deficient cells may be related to direct scavenging of extracellular reactive oxygen and nitrogen species by biliverdin Homo sapiens