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Literature summary extracted from

  • Patel, M.S.; Korotchkina, L.G.; Sidhu, S.
    Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex (2009), J. Mol. Catal. B, 61, 2-6.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.104 D289A the mutant does not have any detectable activity in PDC assay while its activity in thedecarboxylation reaction measured by 2,6-dichlorophenolindophenol assay does not significantly change Homo sapiens
1.2.1.104 D289N the mutant does not demonstrate any change in the 2,6-dichlorophenolindophenol assay but its activity is reduced to 67% in PDC assay Homo sapiens
1.2.1.104 E229A the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
1.2.1.104 E229Q the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
1.2.1.104 E232A the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
1.2.1.104 E232Q the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
1.2.1.104 E234A the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
1.2.1.104 E234Q the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
1.2.1.104 I329A the mutant shows reductions in activities in both the 2,6-dichlorophenolindophenol and PDC assays Homo sapiens
1.2.1.104 I329del the mutant shows reductions in activities in both the 2,6-dichlorophenolindophenol and PDC assays Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.104 additional information Homo sapiens the pyruvate dehydrogenase complex consists of multiple copies of several components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2), dihydrolipoamide dehydrogenase (E3), E3-binding protein (BP), and specific kinases and phosphatases ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 additional information the pyruvate dehydrogenase complex consists of multiple copies of several components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2), dihydrolipoamide dehydrogenase (E3), E3-binding protein (BP), and specific kinases and phosphatases Homo sapiens ?
-
 ?
1.2.1.104 pyruvate + CoA + NAD+
-
 Homo sapiens acetyl-CoA + CO2 + NADH
-
 ?
1.2.1.104 pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
-
 Homo sapiens acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.104 PDC
-
 Homo sapiens
1.2.1.104 PDH
-
 Homo sapiens
1.2.1.104 pyruvate dehydrogenase complex
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 NAD+
-
 Homo sapiens
1.2.1.104 thiamine diphosphate
-
 Homo sapiens