EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.300 | expression in HEK-293 cell | Danio rerio |
1.1.1.300 | expression in HEK-293 cell | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.1.300 | M144G | gain-of-function mutant, enables estrone to bind and be reduced as an additional substrate | Homo sapiens |
1.1.1.300 | M146G | mutation in isoform prRDH1, gain-of-function mutant, enables estrone to bind and be reduced as an additional substrate | Danio rerio |
1.1.1.300 | M147G | mutation in isoform prRDH2, gain-of-function mutant, enables estrone to bind and be reduced as an additional substrate | Danio rerio |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.300 | 0.00126 | - |
all-trans-retinal | wild-type, pH 7.3, 37°C | Homo sapiens | |
1.1.1.300 | 0.0017 | - |
all-trans-retinal | mutant M146G, pH 7.3, 37°C | Danio rerio | |
1.1.1.300 | 0.0023 | - |
all-trans-retinal | mutant M144G, pH 7.3, 37°C | Homo sapiens | |
1.1.1.300 | 0.003 | - |
all-trans-retinal | mutant M147G, pH 7.3, 37°C | Danio rerio | |
1.1.1.300 | 0.0031 | - |
all-trans-retinal | wild-type isoform prRDH1, pH 7.3, 37°C | Danio rerio | |
1.1.1.300 | 0.0044 | - |
all-trans-retinal | wild-type isoform prRDH1, pH 7.3, 37°C | Danio rerio | |
1.1.1.300 | 0.0096 | - |
estrone | mutant M144G, pH 7.3, 37°C | Homo sapiens | |
1.1.1.300 | 0.0233 | - |
estrone | mutant M147G, pH 7.3, 37°C | Danio rerio | |
1.1.1.300 | 0.0307 | - |
estrone | mutant M146G, pH 7.3, 37°C | Danio rerio |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.300 | Danio rerio | - |
- |
- |
1.1.1.300 | Homo sapiens | Q9NYR8 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.300 | all-trans-retinal + NADH + H+ | - |
Danio rerio | all-trans-retinol + NAD+ | - |
? | |
1.1.1.300 | all-trans-retinal + NADH + H+ | - |
Homo sapiens | all-trans-retinol + NAD+ | - |
? | |
1.1.1.300 | estrone + NADH + H+ | no substrate for wild-type isoforms prRDH1 and prRDH2, but substrate for mutants M146G of prRDH1 and M147G of prRDH2 | Danio rerio | estradiol + NAD+ | - |
? | |
1.1.1.300 | estrone + NADH + H+ | no substrate for wild-type, but substrate for mutant M144G | Homo sapiens | estradiol + NAD+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.300 | photoreceptor-associated retinol dehydrogenase | - |
Danio rerio |
1.1.1.300 | photoreceptor-associated retinol dehydrogenase | - |
Homo sapiens |
1.1.1.300 | prRDH | - |
Danio rerio |
1.1.1.300 | prRDH | - |
Homo sapiens |