Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Johnson, T.A.; Qiu, J.; Plaut, A.G.; Holyoak, T.
    Active-site gating regulates substrate selectivity in a chymotrypsin-like serine protease the structure of Haemophilus influenzae IgA1 protease (2009), J. Mol. Biol., 389, 559-574.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.21.72 hanging drop vapor diffusion method, using 0.1 M sodium acetate, pH 5.0, 0.1 M potassium dihydrogen phosphate and 10% (w/v) PEG 20000 Haemophilus influenzae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.72 108700
-
 calculated from amino acid sequence Haemophilus influenzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.72 immunoglobulin A1 + H2O Haemophilus influenzae IgA proteases only cleave the proline, serine and threonine rich hinge peptide unique to immunoglobulin A1 oligopeptides derived from immunoglobulin A1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.72 Haemophilus influenzae P44969 strain Rd 6His
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.72 Ni-NTA agarose column chromatography Haemophilus influenzae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.72 immunoglobulin A1 + H2O IgA proteases only cleave the proline, serine and threonine rich hinge peptide unique to immunoglobulin A1 Haemophilus influenzae oligopeptides derived from immunoglobulin A1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.72 IgA1 protease
-
 Haemophilus influenzae
3.4.21.72 IgAP
-
 Haemophilus influenzae
3.4.21.72 immunoglobulin A1 protease
-
 Haemophilus influenzae