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Literature summary extracted from

  • Arnaud, O.; Koubeissi, A.; Ettouati, L.; Terreux, R.; Alame?, G.; Grenot, C.; Dumontet, C.; Di Pietro, A.; Paris, J.; Falson, P.
    Potent and Fully Noncompetitive Peptidomimetic Inhibitor of Multidrug Resistance P-Glycoprotein (2010), J. Med. Chem., 53, 6720-6729.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 tert-butyl (4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)-L-prolyl-N6-[(benzyloxy)carbonyl]-L-lysinate noncompetitive inhibitor towards daunorubicin and Hoechst 33342 Homo sapiens
7.6.2.2 tert-butyl (4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)-L-prolyl-N6-[(benzyloxy)carbonyl]-L-lysinate noncompetitive inhibitor towards daunorubicin and Hoechst 33342 Mus musculus
7.6.2.2 tetrandrine
-
 Homo sapiens
7.6.2.2 tetrandrine
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-
7.6.2.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 K-562/R7 cell
-
 Homo sapiens
-
7.6.2.2 NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + daunorubicin/in
-
 Mus musculus ADP + phosphate + daunorubicin/out
-
 ?
7.6.2.2 ATP + H2O + daunorubicin/in
-
 Homo sapiens ADP + phosphate + daunorubicin/out
-
 ?
7.6.2.2 ATP + H2O + Hoechst 33342/in
-
 Mus musculus ADP + phosphate + Hoechst 33342/out
-
 ?
7.6.2.2 ATP + H2O + Hoechst 33342/in
-
 Homo sapiens ADP + phosphate + Hoechst 33342/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 P-glycoprotein
-
 Mus musculus
7.6.2.2 P-glycoprotein
-
 Homo sapiens
7.6.2.2 P-gp ABC transporter
-
 Mus musculus
7.6.2.2 P-gp ABC transporter
-
 Homo sapiens