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Literature summary extracted from

  • Deng, L.; Sundriyal, S.; Rubio, V.; Shi, Z.Z.; Song, Y.
    Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (2009), J. Med. Chem., 52, 6539-6542.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.267 1-hydroxy-5-phenylpyridin-2(1H)-one minimal inhibitory concentration for growth 0.02 mM Bacillus anthracis
1.1.1.267 1-hydroxy-5-phenylpyridin-2(1H)-one minimal inhibitory concentration for growth 0.1 mM Escherichia coli
1.1.1.267 1-hydroxy-5-phenylpyridin-2(1H)-one minimal inhibitory concentration for growth 0.1 mM Micrococcus luteus
1.1.1.267 1-hydroxy-5-phenylpyridin-2(1H)-one minimal inhibitory concentration for growth 0.05 mM Pseudomonas aeruginosa
1.1.1.267 4-benzylbenzene-1,2-diol minimal inhibitory concentration for growth 0.2 mM Bacillus anthracis
1.1.1.267 4-benzylbenzene-1,2-diol minimal inhibitory concentration for growth 1 mM Escherichia coli
1.1.1.267 4-benzylbenzene-1,2-diol minimal inhibitory concentration for growth 0.2 mM Micrococcus luteus
1.1.1.267 4-benzylbenzene-1,2-diol minimal inhibitory concentration for growth 0.2 mM Pseudomonas aeruginosa
1.1.1.267 biphenyl-3,4-diol minimal inhibitory concentration for growth 0.2 mM Bacillus anthracis
1.1.1.267 biphenyl-3,4-diol minimal inhibitory concentration for growth 0.5 mM Escherichia coli
1.1.1.267 biphenyl-3,4-diol minimal inhibitory concentration for growth 0.2 mM Micrococcus luteus
1.1.1.267 biphenyl-3,4-diol minimal inhibitory concentration for growth 0.2 mM Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.267 Bacillus anthracis
-
-
-
1.1.1.267 Escherichia coli
-
-
-
1.1.1.267 Micrococcus luteus
-
-
-
1.1.1.267 Pseudomonas aeruginosa
-
-
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.267 0.0014
-
 1-hydroxy-5-phenylpyridin-2(1H)-one pH not specified in the publication, temperature not specified in the publication Escherichia coli
1.1.1.267 0.0224
-
 4-benzylbenzene-1,2-diol pH not specified in the publication, temperature not specified in the publication Escherichia coli
1.1.1.267 0.0447
-
 biphenyl-3,4-diol pH not specified in the publication, temperature not specified in the publication Escherichia coli