Literature summary extracted from

Slotta, J.; Laschke, M.; Wang, Y.; Schilling, M.; Menger, M.; Thorlacius, H.
Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury (2009), J. Investig. Med., 57, 645-649.

Application

EC Number	Application	Comment	Organism
1.1.1.88	medicine	in endotoxemic mice, leukocyte infiltration in the liver is significantly elevated. Simvastatin significantly reduces endotoxin-induced hepatocellular damage and apoptosis. Hepatic accumulation of leukocytes is attenuated by simvastatin. Co-administration of mevalonate abolishes the protective effects of simvastatin on endotoxin-provoked increases in serum alanine transferase and serum alanine transferase as well as leukocyte recruitment	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.88	simvastatin	treatment prevents endotoxemic liver injury by inhibiting leukocyte infiltration and hepatocellular apoptosis. The protective effects are dependent on the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.88	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.88	liver	-	Mus musculus	-

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Release 2023.1 (January 2023)