EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.34 | coactosin-like protein | functions as a 5-LO chaperone | Homo sapiens | |
1.13.11.34 | phosphatidylcholine | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.34 | licofelone | dual COX-2?5-LO inhibitor | Homo sapiens | |
1.13.11.34 | sulindac sulfide | - |
Homo sapiens | |
1.13.11.34 | YS121 | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.13.11.34 | cytosol | when leukocytes are activated to produce leukotrienes, 5-LO moves from the cytosol to the perinuclear membrane | Homo sapiens | 5829 | - |
1.13.11.34 | nuclear outer membrane | when leukocytes are activated to produce leukotrienes, 5-LO moves from the cytosol to the perinuclear membrane | Homo sapiens | 5640 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.34 | Ca2+ | Ca2+ stimulates enzyme activity | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | Homo sapiens | - |
leukotriene A4 + H2O | - |
? | |
1.13.11.34 | arachidonate + O2 | Homo sapiens | - |
(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.34 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.13.11.34 | phosphoprotein | cellular 5-LO activity is regulated by both divalent cations and by phosphorylation, mitogen-activatedprotein kinasesandproteinkinase A can phosphorylate 5-LO in the catalytic domain | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.11.34 | blood | - |
Homo sapiens | - |
1.13.11.34 | leukocyte | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Homo sapiens | leukotriene A4 + H2O | - |
? | |
1.13.11.34 | arachidonate + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.11.34 | 5-lipoxygenase | - |
Homo sapiens |
1.13.11.34 | 5-LO | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.13.11.34 | metabolism | 5-LO has a central role in leukotriene biosynthesis | Homo sapiens |
1.13.11.34 | physiological function | several arachidonic acid metabolites formed via the 5-LO pathway (5-HETE, 5-oxo-ETE, leukotriene B4, leukotriene D4) can promote proliferationof cancer cells | Homo sapiens |