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Literature summary extracted from

  • Akkemik, E.; Budak, H.; Ciftci, M.
    Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study (2010), J. Enzyme Inhib. Med. Chem., 25, 476-479.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.43 4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol non-competitive inhibition Homo sapiens
1.1.1.43 dacarbazine non-competitive inhibition Homo sapiens
1.1.1.43 Furosemide non-competitive inhibition Homo sapiens
1.1.1.43 gadopentetic acid non-competitive inhibition Homo sapiens
1.1.1.43 ketotifen non-competitive inhibition Homo sapiens
1.1.1.43 meloxicam non-competitive inhibition Homo sapiens
1.1.1.43 methotrexate non-competitive inhibition Homo sapiens
1.1.1.43 metochloropramide non-competitive inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.43 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.43 purified 2256times in a yield of 44.22% by using ammonium sulfate precipitation and 2', 5'-ADP Sepharose 4B affinity gel. Temperature of +4°C is maintained during the purification process Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.43 6-phospho-D-gluconate + NADP+
-
 Homo sapiens 6-phospho-2-dehydro-D-gluconate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.43 6PGDH
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.43 NADPH
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.43 0.002
-
 metochloropramide 25°C, pH 8.0, non-competitive inhibition Homo sapiens
1.1.1.43 0.006
-
 4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol 25°C, pH 8.0, non-competitive inhibition Homo sapiens
1.1.1.43 0.008
-
 ketotifen 25°C, pH 8.0, non-competitive inhibition Homo sapiens
1.1.1.43 0.01
-
 dacarbazine 25°C, pH 8.0, non-competitive inhibition Homo sapiens
1.1.1.43 0.05
-
 meloxicam 25°C, pH 8.0, non-competitive inhibition Homo sapiens
1.1.1.43 0.0734
-
 gadopentetic acid 25°C, pH 8.0, non-competitive inhibition Homo sapiens
1.1.1.43 0.127
-
 Furosemide 25°C, pH 8.0, non-competitive inhibition Homo sapiens
1.1.1.43 0.136
-
 methotrexate 25°C, pH 8.0, non-competitive inhibition Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.43 0.008
-
 25°C, pH 8.0, non-competitive inhibition Homo sapiens ketotifen
1.1.1.43 0.01
-
 25°C, pH 8.0, non-competitive inhibition Homo sapiens dacarbazine
1.1.1.43 0.05
-
 25°C, pH 8.0, non-competitive inhibition Homo sapiens meloxicam
1.1.1.43 0.125
-
 25°C, pH 8.0, non-competitive inhibition Homo sapiens Furosemide
1.1.1.43 0.142
-
 25°C, pH 8.0, non-competitive inhibition Homo sapiens methotrexate
1.1.1.43 3.27
-
 25°C, pH 8.0, non-competitive inhibition Homo sapiens metochloropramide
1.1.1.43 3.66
-
 25°C, pH 8.0, non-competitive inhibition Homo sapiens 4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
1.1.1.43 209
-
 25°C, pH 8.0, non-competitive inhibition Homo sapiens gadopentetic acid