EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.1 | 5-fluorouracil + NADH + H+ | Homo sapiens | - |
5-fluoro-5,6-dihydrouracil + NAD+ | dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine | ? | |
1.3.1.2 | dihydrofluorouracil + NADP+ | Homo sapiens | - |
5-fluorouracil + NADPH + H+ | dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.1 | Homo sapiens | - |
- |
- |
1.3.1.2 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.1.1 | HCT-116 cell | colorectal cancer cells | Homo sapiens | - |
1.3.1.2 | HCT-116 cell | colorectal cancer cells | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.1 | 5-fluorouracil + NADH + H+ | - |
Homo sapiens | 5-fluoro-5,6-dihydrouracil + NAD+ | dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine | ? | |
1.3.1.1 | 5-fluorouracil + NADH + H+ | development of a detection method using 2'-fluoro-beta-alanine derivatization with o-phthalaldehyde at room temperature and mass spectrometric analysis by the liquid chromatography-mass spectrometry-electrospray ionization system, method evaluation and optimization, overview | Homo sapiens | 5-fluoro-5,6-dihydrouracil + NAD+ | dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine | ? | |
1.3.1.2 | dihydrofluorouracil + NADP+ | - |
Homo sapiens | 5-fluorouracil + NADPH + H+ | dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine | ? | |
1.3.1.2 | dihydrofluorouracil + NADP+ | development of a detection method using 2'-fluoro-beta-alanine derivatization with o-phthalaldehyde at room temperature and mass spectrometric analysis by the liquid chromatography-mass spectrometry-electrospray ionization system, method evaluation and optimization, overview | Homo sapiens | 5-fluorouracil + NADPH + H+ | dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.1.1 | dihydropyrimidine dehydrogenase | - |
Homo sapiens |
1.3.1.1 | DPD | - |
Homo sapiens |
1.3.1.2 | dihydropyrimidine dehydrogenase | - |
Homo sapiens |
1.3.1.2 | DPD | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.1 | NAD+ | - |
Homo sapiens | |
1.3.1.2 | NADPH | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.3.1.1 | metabolism | efficacy of the chemotherapeutic drug 5'-fluorouracil is reduced by catabolism to 2'-fluoro-beta-alanine, a three-step reaction in which dihydropyrimidine dehydrogenase catalyzes the rate limiting step | Homo sapiens |
1.3.1.2 | metabolism | efficacy of the chemotherapeutic drug 5'-fluorouracil is reduced by catabolism to 2'-fluoro-beta-alanine, a three-step reaction in which dihydropyrimidine dehydrogenase catalyzes the ratelimiting step | Homo sapiens |