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Literature summary extracted from
- Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening (2009), J. Cell. Biochem., 107, 253-263.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.107 | expressed in Escherichia coli | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.107 | AEBSF | - |
Homo sapiens |  |
| 3.4.21.107 | additional information | not inhibited by benzyloxycarbonyl-VAD-fluoromethylketone | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.107 | microtubule | HtrA1 is localized to microtubules in both interphase and mitotic cells | Homo sapiens | 5874 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | alpha-tubulin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.107 | beta-tubulin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.107 | gamma-tubulin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.107 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.107 | OV-202 cell | - |
Homo sapiens | - |
| 3.4.21.107 | SKOV-3 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | alpha-tubulin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.107 | beta-tubulin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.107 | gamma-tubulin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | HtrA1 | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | physiological function | HtrA1 is implicated in trophoblast cell migration and invasion, tumor progression, chemotherapy-induced cytotoxicity, osteoarthritis, age-related macular degeneration, and pathogenesis of Alzheimer's disease | Homo sapiens |
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Release 2023.1 (January 2023)
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