EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.1.98 | - |
Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.5.1.98 | D176A | the mutation increases the K1/2 for potassium inhibition by more than 40fold | Homo sapiens |
3.5.1.98 | H142A | the mutation increases the K1/2 for potassium inhibition by more than 40fold | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.98 | K+ | K+ bound to monovalent cation site 1 inhibits catalytic activity of HDAC8 (11fold less active with two K+ ions bound compared to one K+ ion bound), partial inhibition at high KCl | Homo sapiens | |
3.5.1.98 | suberoylanilide hydroxamic acid | - |
Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.98 | K+ | K+ bound to monovalent cation site 2 enhances catalytic activity of HDAC8 45fold with maximal deacetylase activity observed at 10 mM KCl. K+ is the predominant monovalent cation bound to HDAC8 in vivo, K+ binding to site 1 enhances the affinity of HDAC8 for suberoylanilide hydroxamic acid | Homo sapiens | |
3.5.1.98 | Na+ | Na+ binds more weakly to both monovalent cation sites and activates HDAC8 to a lesser extent than K+ | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.98 | Homo sapiens | - |
- |
- |
EC Number | Oxidation Stability | Organism |
---|---|---|
3.5.1.98 | Co(2+)-HDAC8 is stable in the presence of oxygen | Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.1.98 | - |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.98 | Fluor de Lys H4-AcK16 + H2O | - |
Homo sapiens | ? | - |
? | |
3.5.1.98 | Fluor de Lys HDAC8 substrate + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.1.98 | HDAC8 | - |
Homo sapiens |
3.5.1.98 | histone deacetylase 8 | - |
Homo sapiens |