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Literature summary extracted from

  • Pike, S.T.; Rajendra, R.; Artzt, K.; Appling, D.R.
    Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos (2010), J. Biol. Chem., 285, 4612-4620.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.4.9 mitochondrion
-
 Mus musculus 5739
-
6.3.2.17 mitochondrion MTHFD1L enzyme is present and functional in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines Mus musculus 5739
-
6.3.4.3 mitochondrion MTHFD1L enzyme is present in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines, and embryonic mitochondria possess the ability to synthesize formate from glycine. Greater than 75% of 1-C units entering the cytoplasmic methyl cycle are mitochondrially derived Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Mus musculus
-
 10-formyltetrahydrofolate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.9 Mus musculus
-
-
-
6.3.2.17 Mus musculus
-
-
-
6.3.4.3 Mus musculus Q3V3R1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.9 embryo
-
 Mus musculus
-
6.3.2.17 embryo the MTHFD1L transcript is detected at all stages of mouse embryogenesis examined Mus musculus
-
6.3.2.17 embryonic cell line
-
 Mus musculus
-
6.3.4.3 embryo the MTHFD1L transcript is detected at all stages of mouse embryogenesis examined. MTHFD1L is expressed ubiquitously throughout the embryo but with localized regions of higher expression. The spatial pattern of MTHFD1L expression is virtually indistinguishable from that of MTHFD2 and cytoplasmic C1-THF synthase MTHFD1 in embryonic day 9.5 mouse embryos Mus musculus
-
6.3.4.3 fibroblast embryonic fibroblast cell line Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
 Mus musculus 10-formyltetrahydrofolate
-
 r

Synonyms

EC Number Synonyms Comment Organism
3.5.4.9 5,10-methenyl-THF cyclohydrolase
-
 Mus musculus
3.5.4.9 methenyl-tetrahydrofolate cyclohydrolase
-
 Mus musculus
3.5.4.9 methenyl-THF cyclohydrolase
-
 Mus musculus
3.5.4.9 MTHFD2 bifunctional enzyme possessing methenyl-tetrahydrofolate cyclohydrolase and dehydrogenase activities Mus musculus
6.3.2.17 Folylpolyglutamate synthetase
-
 Mus musculus
6.3.2.17 MTHFD1L
-
 Mus musculus
6.3.4.3 MTHFD1L
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
3.5.4.9 NAD+ dependent on Mus musculus

Expression

EC Number Organism Comment Expression
3.5.4.9 Mus musculus MTHFD2 expression is high during early development but decreases as birth approaches down