Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Li, H.; Kundu, T.K.; Zweier, J.L.
    Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite (2009), J. Biol. Chem., 284, 33850-33858.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.3.1 raloxifene inhibits substrate binding at the molybdenum site of the enzyme Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.3.1 0.0096
-
 4-(dimethylamino)cinnamaldehyde in the presence of 1 mM nitrite, at pH 6.0 and 37°C Rattus norvegicus
1.2.3.1 0.024
-
 NADH in the presence of 1 mM nitrite, at pH 6.0 and 37°C Rattus norvegicus
1.2.3.1 2.7
-
 nitrite in the presence of 0.1 mM NADH, at pH 6.0 and 37°C Rattus norvegicus
1.2.3.1 3.3
-
 nitrite in the presence of 0.05 mM 4-(dimethylamino)cinnamaldehyde, at pH 6.0 and 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.3.1 cytosol
-
 Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.3.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.3.1 4-(dimethylamino)cinnamaldehyde + H2O + O2
-
 Rattus norvegicus ?
-
 ?
1.2.3.1 4-(dimethylamino)cinnamaldehyde + nitrite + H2O + O2 in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide Rattus norvegicus ? + nitric oxide
-
 ?
1.2.3.1 NADH + nitrite + H2O + O2 in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide. NADH reacts with aldehyde oxidase at the FAD site of the enzyme Rattus norvegicus ? + nitric oxide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.3.1 aldehyde:oxygen oxidoreductase
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.3.1 6
-
 maximum aldehyde oxidase-catalyzed nitric oxide generation occurs at pH 6.0 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.3.1 5 8 maximum aldehyde oxidase-catalyzed nitric oxide generation occurs at pH 6.0. When the pH is decreased to 5.0 or increased above 8.0, a decrease in the rate of nitric oxide generation is observed Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.3.1 FAD
-
 Rattus norvegicus