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Literature summary extracted from

  • Filipe, S.R.; Severina, E.; Tomasz, A.
    Functional analysis of Streptococcus pneumoniae MurM reveals the region responsible for its specificity in the synthesis of branched cell wall peptides (2001), J. Biol. Chem., 276, 39618-39628.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.B1 Streptococcus pneumoniae Q9L447
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.B1 additional information a 30-amino acid long sequence within the MurM protein is the main determinant of the specificity of the reaction, the addition of alanine versus serine Streptococcus pneumoniae ?
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General Information

EC Number General Information Comment Organism
2.3.2.B1 physiological function the muropeptide composition of the pneumococcal cell walls is determined by the particular murM allele carried by the cells. After cloning of different murM alleles from several penicillin-resistant Streptococcus pneumoniae strains, each with a characteristic branched peptide pattern, and transformation into the penicillin-susceptible laboratory strain R36A, all transformants remain penicillin-susceptible, their cell wall composition changing in directions corresponding to the muropeptide pattern of the strain from which the murM allele is derived Streptococcus pneumoniae