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Literature summary extracted from

  • Chung, S.P.; Sogabe, K.; Park, H.K.; Song, Y.; Ono, K.; Abou El-Magd, R.M.; Shishido, Y.; Yorita, K.; Sakai, T.; Fukui, K.
    Potential cytotoxic effect of hydroxypyruvate produced from D-serine by astroglial D-amino acid oxidase (2010), J. Biochem., 148, 743-753.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.3 quantitative real-time PCR expression analysis in different cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.3 peroxisome
-
 Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-serine + H2O + O2 Rattus norvegicus
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 additional information Rattus norvegicus the flavoenzyme catalyzes the oxidative deamination of neutral and basic D-amino acids to the corresponding 2-oxo acids and H2O2 with concomitant reduction of FAD ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 astrocyte in lower brain stem and cerebellum, as well as type-1 astrocytes from cerebral cortex and the cerebellum Rattus norvegicus
-
1.4.3.3 astroglial cell
-
 Rattus norvegicus
-
1.4.3.3 brain
-
 Rattus norvegicus
-
1.4.3.3 C6 glioma cell glioma cells Rattus norvegicus
-
1.4.3.3 H4TG cell a derivative of the H4-IIE-C3 rat hepatoma cell line Rattus norvegicus
-
1.4.3.3 kidney
-
 Rattus norvegicus
-
1.4.3.3 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-serine + H2O + O2
-
 Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 additional information the flavoenzyme catalyzes the oxidative deamination of neutral and basic D-amino acids to the corresponding 2-oxo acids and H2O2 with concomitant reduction of FAD Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.3 ? x * 38500-39000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAO
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.4.3.3 additional information metabolism of extracellular D-serine and effects of D-serine metabolites with pathophysiological role of DAO, overexpression of DAO in astroglial cells induces the enhanced cytotoxicity, reaction product beta-hydroxypyruvate also induces cell death, comprising apoptosis, in the astroglial cell, but not in the other cells derived from liver and kidney, overview Rattus norvegicus